Abstract
This study aimed to evaluate the efficacy of intravenous (IV) and nebulized magnesium sulfate in acute asthma in children. The PubMed, Cochrane Library, and EMBASE databases were searched. Randomized controlled trials and quasi-randomized controlled trials of IV and nebulized magnesium sulfate in pediatric acute asthma were included. The outcomes subject to meta-analysis were pulmonary function, hospitalization, and further treatment. If statistical heterogeneity was significant, random-effects models were used for meta-analysis, otherwise, fixed-effects models were applied. Ten randomized and quasi-randomized trials (6 IV, 4 nebulized) were identified. Intravenous magnesium sulfate treatment is associated with significant effects on respiratory function (standardized mean difference, 1.94; 95% confidence interval [CI], 0.80-3.08; P = 0.0008) and hospital admission (risk ratio, 0.55; 95% CI, 0.31-0.95; P = 0.03). But nebulized magnesium sulfate treatment shows no significant effect on respiratory function (standardized mean difference, 0.19; 95% CI, -0.01-0.40; P = 0.07) or hospital admission (risk ratio, 1.11; 95% CI, 0.86-1.44; P = 0.42). The meta-analysis revealed that IV magnesium sulfate is an effective treatment in childr...Continue Reading
References
Apr 1, 1987·Allergy·G RollaS Spinaci
Dec 1, 1996·The Journal of Pediatrics·L CiaralloM W Shannon
Jan 6, 2000·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·F GürkanA Ece
Oct 13, 2000·Archives of Pediatrics & Adolescent Medicine·L CiaralloS Reinert
Nov 30, 2000·Annals of Emergency Medicine·R J ScarfoneE J Gracely
May 24, 2001·Clinical Pharmacology and Therapeutics·P SchenkR Smetana
Nov 6, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·K I GourgoulianisP A Molyvdas
Aug 13, 2002·Chest·Robert A SilvermanUNKNOWN Acute Asthma/Magnesium Study Group
Jun 27, 2003·Lancet·Rodney HughesRichard Beasley
Oct 8, 2003·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Paul A SimonJonathan E Fielding
Jun 29, 2004·The Journal of Emergency Medicine·Prashant MahajanRonald Thomas
Dec 23, 2004·Archives of Disease in Childhood·D K L CheukS L Lee
Apr 22, 2006·Emergency Medicine Journal : EMJ·P AggarwalM Irshad
Aug 29, 2006·Lancet·M Innes AsherUNKNOWN ISAAC Phase Three Study Group
Nov 22, 2007·Emergency Medicine Journal : EMJ·S Mohammed, S Goodacre
Jan 8, 2013·Respiratory Medicine·Zhilei ShanLiegang Liu
Dec 18, 2013·Journal of Tropical Pediatrics·Y X SunJ H Dai
Jan 17, 2014·The Lancet. Respiratory Medicine·Colin PowellUNKNOWN MAGNETIC study group
Apr 16, 2014·Health Technology Assessment : HTA·Steve GoodacreUNKNOWN 3Mg Research Team
Citations
Dec 16, 2020·Biological Trace Element Research·Daniela FanniG Faa
Jan 27, 2021·Pediatric Pulmonology·Carlos E Rodriguez-Martinez, Monica P Sossa-Briceño
Nov 25, 2020·JAMA : the Journal of the American Medical Association·Suzanne SchuhUNKNOWN Pediatric Emergency Research Canada (PERC) Network
Jan 7, 2021·Pediatric Quality & Safety·Emily Altick HartfordLori E Rutman
Oct 19, 2019·Pediatric Pulmonology·Sriram RamgopalSylvia Owusu-Ansah
May 29, 2020·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Christine A KapuscinskiDavid J Hutchinson
Jun 12, 2020·Journal of Veterinary Pharmacology and Therapeutics·Stephen A SchumacherAlicia L Bertone
Aug 9, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Nicole M AcquistoMichael C Thomas
Dec 5, 2019·European Journal of Pediatrics·Shelley BoeschotenCorinne Buysse
Dec 19, 2018·American Journal of Respiratory and Critical Care Medicine·J Michael RamsahaiPeter A B Wark
Aug 14, 2020·Pediatric Pulmonology·Jefferson A BuendiaCarlos E Rodriguez-Martinez
Feb 14, 2018·The European Respiratory Journal·Hannele PruikkonenMarjo Renko
Dec 19, 2019·Frontiers in Veterinary Science·Stephen A SchumacherAlicia L Bertone
Mar 31, 2020·The American Journal of Emergency Medicine·Brit LongMichael Gottlieb
Mar 30, 2021·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Luis MoralJosé Valverde-Molina
Jul 20, 2021·JAMA Network Open·Suzanne SchuhUNKNOWN Pediatric Emergency Research Canada
Jul 17, 2021·The American Journal of Emergency Medicine·Amy M DeLarocheKatherine Obudzinski
Aug 7, 2021·Anales De Pediatría·Luis MoralJosé Valverde-Molina
Sep 5, 2021·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Sarah Anderson, Elizabeth Farrington
Feb 19, 2020·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Ali Özdemir, Dilek Doğruel
Nov 23, 2021·Hospital Pediatrics·Elizabeth E HalvorsonJoel S Tieder