PMID: 3756044Sep 1, 1986Paper

Intravenous and oral amiodarone for arrhythmias in children

British Heart Journal
C A BucknallD W Holt

Abstract

Oral amiodarone was administered to 30 children (aged one week to 14 years) for treatment of resistant or life threatening tachycardias. Five children received initial intravenous medication. The mean duration of oral treatment ranged from two weeks to 64 months (mean 23 months). Infants required a higher oral dose than older children when this was calculated on the basis of body weight but not when it was calculated on the basis of body surface area, indicating that the prescribed dose of amiodarone for infants should be calculated on the basis of body surface area. Although plasma concentrations of amiodarone were similar in infants and children, the plasma concentration of the metabolite desethylamiodarone was lower in infants. The arrhythmias were effectively controlled, by amiodarone alone in 19 and by amiodarone in combination with other drugs in nine children; amiodarone was ineffective in the remaining two children. Unwanted effects were common but were not significantly related to the dose, duration of treatment, or plasma concentration of amiodarone when group results were analysed. Grey facial skin pigmentation developed in two patients who received high cumulative doses of amiodarone and in whom plasma concentration...Continue Reading

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References

Dec 1, 1976·The American Journal of Cardiology·M B RosenbaumM V Elizari
Jan 1, 1983·Circulation·L HarrisD M Krikler
Oct 1, 1984·Journal of the American College of Cardiology·A GarsonH M Hittner
Jul 16, 1983·British Medical Journal·B McGovernJ N Ruskin
Oct 1, 1983·American Heart Journal·D W HoltG C Storey
Oct 1, 1983·American Heart Journal·D V Ingram
Jul 1, 1983·Clinical Pediatrics·B Sharda, B Bhandari

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Citations

Mar 1, 1995·Pediatric Cardiology·A Pohlgeers, J Villafane
Oct 1, 1992·Pediatric Cardiology·Z M HijaziC S Kleinman
Jun 10, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Nikolaus A Haas, Christoph K Camphausen
Apr 1, 1990·Journal of the American College of Cardiology·P GuccioneA Garson
Sep 1, 1990·Journal of the American College of Cardiology·V L ZeiglerD A Fyfe
Jan 3, 2001·Clinics in Dermatology·S R Porter, C Scully
Jan 20, 1999·Acta Paediatrica Japonica; Overseas Edition·A CelikerS Ozme
Feb 1, 1987·British Heart Journal·C Wren, R W Campbell
Jul 1, 1993·British Heart Journal·J M McComb
Oct 22, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Aya MiyazakiOsamu Yamada
Feb 14, 2012·Expert Opinion on Drug Safety·Pasquale SantangeliAndrea Natale
Sep 15, 1994·The American Journal of Cardiology·F H FigaR M Freedom
Sep 11, 1991·The American Journal of Cardiology·G PongiglioneD W Benson
May 1, 1989·Progress in Cardiovascular Diseases·T R VrobelL Rakita
Jan 1, 1989·Progress in Cardiovascular Diseases·A Kadish, F Morady
Sep 1, 1988·International Journal of Cardiology·C J Foster, H G Love
Jul 31, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·C Scully, J-V Bagan
Sep 2, 2017·Paediatric Drugs·Chalese Richardson, Eric S Silver
Dec 1, 2005·Circulation·J Philip SaulUNKNOWN Intravenous Amiodarone Pediatric Investigators
May 11, 2010·Pediatric Emergency Care·Roni D LaneMarianne Gausche-Hill
Sep 23, 2018·Pediatric Cardiology·Julia GesingWieland Kiess
Sep 12, 2007·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Walter KnirschUrs Bauersfeld

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