Intravenous and subcutaneous administration of a long-acting somatostatin analogue: effects on glucose metabolism and splanchnic haemodynamics in healthy subjects

European Journal of Clinical Investigation
L S Eriksson, J Wahren

Abstract

The effect of SMS 201-995, a long-acting somatostatin analogue, on splanchnic blood flow and glucose metabolism, was investigated in five groups of healthy subjects. Groups A (n = 4), B (n = 5), C (n = 5) and D (n = 5) were studied before, during and after a 60-min intravenous infusion of SMS (1.7, 0.8, 0.2 and 0.1 micrograms min-1, respectively). Group E (n = 6) was investigated before and for 6 h after a subcutaneous injection of 25 micrograms of SMS. The splanchnic blood flow decreased by 20-25% in all groups in response to SMS and remained low during the entire observation periods. Arterial concentrations of glucose showed a 15-20% decline during SMS infusion in Groups A and B (P less than 0.05-0.01) and a less pronounced decrease in the other groups. Fifteen minutes after the end of infusion the glucose levels started to rise and in group A, the levels were significantly higher than basal (+25%, P less than 0.05-0.01) at 90-180 min after the end of infusion. The net splanchnic glucose production, determined in groups A and B, decreased by 65-75% in response to SMS infusion. Towards the end and immediately after the infusions, however, the net glucose output increased, but decreased again at 30-60 min after the end of infus...Continue Reading

References

Aug 1, 1978·The Journal of Clinical Investigation·G I ShulmanA D Cherrington
Jan 1, 1978·Acta Radiologica: Diagnosis·S Efendić, O Mattsson
Sep 1, 1978·The Journal of Clinical Investigation·A D CherringtonJ L Chiasson
Jan 3, 1985·The New England Journal of Medicine·P N MatonR T Jensen
Jan 1, 1985·Advances in Experimental Medicine and Biology·P MarbachJ Pless
Dec 23, 1985·Life Sciences·K N Dileepan, S R Wagle
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·K KutzJ Rosenthaler
Oct 1, 1987·Scandinavian Journal of Gastroenterology·L S ErikssonJ Wahren
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
May 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D KravetzJ Rodés
Feb 26, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·G Svensson, T Anfält

❮ Previous
Next ❯

Citations

Mar 1, 1995·Diseases of the Colon and Rectum·S YamanerE Ademoğlu
Apr 5, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Nanouk G M WiemerMichiel Dubbelman
Jan 27, 2010·European Journal of Applied Physiology·Sara S Jarvis, James A Pawelczyk
Feb 13, 2001·Diabetes Research and Clinical Practice·D BruttomessoS Del Prato
Dec 5, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·J BurggraafA F Cohen
Nov 26, 2002·Liver·Lene SimonsenJens Bülow
Feb 1, 1996·Journal of Endocrinological Investigation·J DonckierA A Charlier
Mar 20, 2014·The American Journal of Gastroenterology·Christian S Jackson, Lauren B Gerson
Sep 24, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Jacob T GutscheJohn G Augoustides
Jan 28, 2015·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Xihua YangSteven C Cunningham
Jul 22, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Matthew T McMillanCharles M Vollmer
Sep 1, 1992·Metabolism: Clinical and Experimental·K E Gyr, R Meier
Aug 1, 1994·Journal of Pain and Symptom Management·S Mercadante
Feb 22, 2007·The American Journal of Gastroenterology·Félix JunqueraJuan-Ramón Malagelada

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.