PMID: 12877769Jul 25, 2003Paper

Intravenous angiotensin II does not affect dynamic baroreflex characteristics of the neural or peripheral arc

The Japanese Journal of Physiology
Koji KashiharaK Sunagawa

Abstract

Although the elevation of angiotensin II (Ang II) associated with cardiovascular diseases has been considered to suppress the arterial baroreflex function, how Ang II affects dynamic arterial pressure (AP) regulation remains unknown. The aim of the present study was to elucidate the acute effects of Ang II on dynamic AP regulation by the arterial baroreflex. In seven anesthetized Japanese white rabbits, we randomly perturbed intra-carotid sinus pressure (CSP) according to a binary white noise sequence while recording renal sympathetic nerve activity (RSNA) and AP. We estimated the neural arc transfer function from CSP to RSNA and the peripheral arc transfer function from RSNA to AP before and after 30-min intravenous administration of Ang II (100 ng/kg/min). Ang II increased mean AP from 75.7 +/- 3.1 to 95.5 +/- 5.1 mmHg (p < 0.01), while it did not affect mean RSNA (from 5.9 +/- 1.3 to 5.7 +/- 1.2 a.u.). The neural arc transfer functions did not differ before or after Ang II administration (dynamic gain: -0.94 +/- 0.04 vs. -0.94 +/- 0.13, corner frequency: 0.06 +/- 0.01 vs.0.06 +/- 0.01 Hz, pure delay: 0.16 +/- 0.01 vs. 0.17 +/- 0.02 s). The peripheral arc transfer function did not differ before or after Ang II administration ...Continue Reading

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Feb 9, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Toru KawadaKenji Sunagawa
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Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Toru KawadaKenji Sunagawa

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Citations

Nov 13, 2008·Annals of Biomedical Engineering·Koji KashiharaKenji Sunagawa
Nov 7, 2015·The Journal of Physiological Sciences : JPS·Toru Kawada, Masaru Sugimachi
Feb 14, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Toru KawadaKenji Sunagawa
May 13, 2008·The Journal of Physiological Sciences : JPS·Atsunori KamiyaMasaru Sugimachi
Nov 5, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Toru KawadaMasaru Sugimachi
Mar 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Toru KawadaMasaru Sugimachi

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