Intravenous Arginine Administration Promotes Proangiogenic Cells Mobilization and Attenuates Lung Injury in Mice with Polymicrobial Sepsis

Nutrients
Chiu-Li YehSung-Ling Yeh

Abstract

This study investigated the influence of intravenous arginine (Arg) administration on alteration of circulating proangiogenic cells and remote lung injury in a model of polymicrobial sepsis. Mice were assigned to one normal control group (NC) and two sepsis groups that were induced by cecal ligation and puncture (CLP). One of the sepsis groups was injected with saline (SS), whereas the other (SA) was administered with a single bolus of 300 mg Arg/kg body weight via the tail vein 1 h after CLP. Septic mice were sacrificed at either 24 or 48 h after CLP, with their blood and lung tissues collected for analysis. Results showed that septic groups had higher proangiogenic cells releasing factors and proangiogenic cells percentage in blood. Also, concentration of inflammatory cytokines and expression of angiopoietin (Angpt)/Tie-2 genes in lung tissues were upregulated. Arg administration promoted mobilization of circulating proangiogenic cells while it downregulated the production of inflammatory cytokines and expression of Angpt/Tie-2 genes in the lung. The results of this investigation suggested that intravenous administration of Arg shortly after the onset of sepsis enhanced the mobilization of circulating proangiogenic cells, mai...Continue Reading

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Citations

Oct 5, 2017·Nutrients·Helieh S Oz
Nov 24, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ran SunBingwei Sun
Jun 2, 2021·DNA and Cell Biology·Lin-Zhen XiaZuo Wang

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Methods Mentioned

BETA
Enzyme-Linked ImmunoSorbent Assay
ELISA
PCR

Software Mentioned

GraphPad Prism
Pro Plus
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