PMID: 11907183Mar 22, 2002Paper

Intravenous buprenorphine self-administration by detoxified heroin abusers

The Journal of Pharmacology and Experimental Therapeutics
Sandra D ComerMarian W Fischman

Abstract

Several sources indicate that intravenously administered buprenorphine may have significant abuse liability in humans. The present study evaluated the reinforcing effects of intravenously administered buprenorphine (0, 2, and 8 mg) in detoxified heroin-dependent participants during a 7.5-week inpatient study. Participants (n = 6) were detoxified from heroin over a 1.5-week period immediately after admission. Testing subsequently occurred in three 2-week blocks. During the first week of each 2-week block, the reinforcing effects of buprenorphine were evaluated. Participants first received a dose of buprenorphine and $20 and then were given either the opportunity to self-administer the dose or $20 during choice sessions. During the second week of each 2-week block, the direct effects of heroin were measured to evaluate potential long-lasting antagonist effects of buprenorphine. Progressive ratio break-point values were significantly higher after 2 and 8 mg of buprenorphine compared with placebo. Correspondingly, several positive subjective ratings increased after administration of active buprenorphine relative to placebo. Although there were few differences in peak effects produced by 2 versus 8 mg of buprenorphine, the higher bu...Continue Reading

References

Jul 1, 1992·Acta Psychiatrica Scandinavica·R A SinghV K Varma
May 27, 1992·JAMA : the Journal of the American Medical Association·R E JohnsonP J Fudala
Apr 1, 1989·British Journal of Addiction·M S SakolR Sykes
May 1, 1989·Clinical Pharmacology and Therapeutics·D R JasinskiR E Johnson
Sep 1, 1988·British Journal of Addiction·J J O'ConnorA Campbell
Sep 1, 1987·Drug and Alcohol Dependence·Y BlomL M Gunne
Jan 1, 1987·European Journal of Clinical Pharmacology·U Saarialho-KereT Seppälä
Jun 1, 1995·Psychopharmacology·S L WalshM L Stitzer
Jul 1, 1994·The American Journal of Psychiatry·E C StrainG E Bigelow
May 1, 1994·Clinical Pharmacology and Therapeutics·S L WalshG E Bigelow
May 1, 1993·Clinical Pharmacology and Therapeutics·W B PickworthE J Cone
May 1, 1996·Archives of General Psychiatry·W LingC J Klett
Feb 1, 1997·Psychopharmacology·E C StrainG E Bigelow
Jun 1, 1997·Biological Psychiatry·J MendelsonS L Batki
Jul 1, 1997·The Annals of Pharmacotherapy·M BaumevieilleB Bégaud
May 21, 1998·European Journal of Pharmacology·S D ComerM W Fischman
Dec 2, 1998·Behavioural Pharmacology·S D ComerM W Fischman
Feb 1, 1994·Behavioural Pharmacology·R.W. Foltin, M.W. Fischman
May 16, 2001·Psychopharmacology·K B StollerE C Strain

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Citations

Feb 20, 2008·Psychopharmacology·Margaret Haney, Roger Spealman
Nov 13, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
May 10, 2003·Drug and Alcohol Dependence·Sharon L Walsh, Thomas Eissenberg
May 10, 2003·Drug and Alcohol Dependence·Rolley E JohnsonLeslie Amass
Feb 3, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Scott A ChenGeorge F Koob
Jun 22, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sandra D ComerWilliam J Kowalczyk
Sep 5, 2003·The New England Journal of Medicine·Paul J FudalaUNKNOWN Buprenorphine/Naloxone Collaborative Study Group
Apr 26, 2008·Drug and Alcohol Dependence·S D ComerS L Walsh
Jul 15, 2003·The American Journal on Addictions·Herbert D Kleber
Jun 24, 2008·European Journal of Pain : EJP·Hans G Kress
Sep 27, 2005·Pharmacology & Therapeutics·Charles P O'Brien, Eliot L Gardner
May 27, 2004·Natural Product Reports·Kenneth W Bentley
Oct 1, 2005·Expert Review of Pharmacoeconomics & Outcomes Research·Christopher M Doran
Apr 22, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Soichiro IdeKazutaka Ikeda
Oct 25, 2017·JAAPA : Official Journal of the American Academy of Physician Assistants·Eric Urnoski
Apr 29, 2016·Journal of Psychiatric Practice·Xiaofan LiThomas R Kosten
Sep 8, 2005·The Journal of Pharmacology and Experimental Therapeutics·Sandra D ComerEllen A Walker
Oct 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Sandra D Comer, Eric D Collins
Mar 25, 2020·Psychological Medicine·Caitlin A Madison, Shoshana Eitan
Nov 1, 2020·Drug and Alcohol Dependence·Claudia MariottiniIlkka Ojanperä

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