Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy

Stem Cells International
Adam C VandergriffKe Cheng

Abstract

Despite the efficacy of cardiac stem cells (CSCs) for treatment of cardiomyopathies, there are many limitations to stem cell therapies. CSC-derived exosomes (CSC-XOs) have been shown to be responsible for a large portion of the regenerative effects of CSCs. Using a mouse model of doxorubicin induced dilated cardiomyopathy, we study the effects of systemic delivery of human CSC-XOs in mice. Mice receiving CSC-XOs showed improved heart function via echocardiography, as well as decreased apoptosis and fibrosis. In spite of using immunocompetent mice and human CSC-XOs, mice showed no adverse immune reaction. The use of CSC-XOs holds promise for overcoming the limitations of stem cells and improving cardiac therapies.

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Citations

Jan 18, 2016·Journal of Molecular and Cellular Cardiology·Emily Ongstad, Peter Kohl
Mar 23, 2017·Biotechnology and Applied Biochemistry·Shalini RaikShalmoli Bhattacharyya
Nov 1, 2016·Cardiovascular Drugs and Therapy·Sean M DavidsonDerek M Yellon
Jul 10, 2020·Biomarkers in Medicine·Xi-Ji QinRui-Lan Wang
Aug 5, 2020·Journal of Cellular and Molecular Medicine·Chi ZhangWenqi Song
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Apr 18, 2019·International Journal of Molecular Sciences·Stefania RaimondoRiccardo Alessandro
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Aug 5, 2020·Signal Transduction and Targeted Therapy·Biting ZhouShu Zheng
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Nov 17, 2020·Frontiers in Bioengineering and Biotechnology·Philippe Menasché
Nov 22, 2020·Trends in Molecular Medicine·Chloé PezzanaPhilippe Menasché
Mar 7, 2021·International Journal of Molecular Sciences·Matthias Mietsch, Rabea Hinkel
Apr 7, 2021·Nature Biomedical Engineering·Shiqi HuKe Cheng
Jun 22, 2021·Frontiers in Bioengineering and Biotechnology·Mira ChingaleKe Huang
Feb 4, 2016·Circulation Research·Raj Kishore, Mohsin Khan
May 28, 2019·Accounts of Chemical Research·Zhenhua LiKe Cheng
Aug 29, 2021·Pharmaceuticals·Emanuela DiomaiutoAntonio Di Loria
Jan 19, 2021·ACS Biomaterials Science & Engineering·Camilo Mora-NavarroDonald O Freytes

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

SCIPIO
Graphpad Prism

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