Intravenous cyclosporine versus intravenous corticosteroids as single therapy for severe attacks of ulcerative colitis

Gastroenterology
G D'HaensP Rutgeerts

Abstract

Cyclosporine has been effective in patients with steroid-refractory attacks of ulcerative colitis (UC). We investigated the effects of intravenous (IV) cyclosporine as single IV therapy (without glucocorticosteroids) for severe UC and compared these with the response to glucocorticosteroids. Patients with a severe attack of UC were randomized to treatment with IV cyclosporine, 4 mg x kg(-1) x day(-1), or with methylprednisolone, 40 mg/day, in a randomized, double-blind, controlled trial. After 8 days, patients who had a response received the same medication orally in combination with azathioprine. Patients were followed up clinically, endoscopically, and by scintigraphy. Renal function was assessed using urinary inulin clearances. Endpoints were clinical improvement, discharge from the hospital, and remission up to 12 months after intravenous therapy. Thirty patients were included. After 8 days, 8 of 15 patients (53%) who received methylprednisolone had a response to therapy vs. 9 of 14 (64%) receiving cyclosporine. In nonresponders, 3 of 7 methylprednisolone patients and 1 of 3 cyclosporine patients improved when both treatments were combined. No serious drug-related toxicity was observed with either treatment. At 12 months, 7...Continue Reading

Citations

Oct 22, 2009·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Yogesh Suresh Punekar, Neil Hawkins
Nov 7, 2001·Current Gastroenterology Reports·P Y Chung, R D Cohen
Nov 16, 2006·Current Gastroenterology Reports·Geoffrey C NguyenThemistocles Dassopoulos
Jul 27, 2011·Current Gastroenterology Reports·Frank HoentjenStephen Hanauer
May 20, 2004·Current Treatment Options in Gastroenterology·Karl H. Kim, Gary R. Lichtenstein
Jun 6, 2007·Current Treatment Options in Gastroenterology·Stephen B Hanauer, Arnold Wald
Feb 20, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·R N Fedorak
May 17, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S Vermeire
Feb 7, 2002·Lancet·Richard J Farrell, Mark A Peppercorn
Oct 16, 2012·Lancet·David LaharieUNKNOWN Groupe d'Etudes Thérapeutiques des Affections Inflammatoires Digestives
Oct 31, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·J Simmons, D P Jewell
Oct 31, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A KohnM Daperno
Oct 22, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S Campbell, S Ghosh
Jul 5, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F RizzelloP Gionchetti
Feb 1, 2004·Clinics in Colon and Rectal Surgery·Uma Mahadevan
Nov 22, 2011·Journal of Gastroenterology and Hepatology·Kathryn E DeanRussell S Walmsley
Feb 23, 2012·Journal of Gastroenterology and Hepatology·Richard B Gearry, James D Falvey
Oct 29, 2008·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S R BrownUNKNOWN ACPGBI
Jan 10, 2002·Clinical Microbiology Reviews·Barbara A HendricksonJudy H Cho
Dec 14, 2002·BMJ : British Medical Journal·Paul Moayyedi, Alex Ford
Aug 13, 2004·Gut·M J CarterUNKNOWN IBD Section, British Society of Gastroenterology
Aug 15, 2006·Gut·K R HerrlingerE F Stange
Jan 14, 2003·Gut·C G LoftusW J Sandborn
Jun 15, 2007·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Toshifumi Hibi, Makoto Naganuma
Jan 18, 2008·World Journal of Gastroenterology : WJG·Patricia L Kozuch, Stephen B Hanauer
Sep 24, 2008·World Journal of Gastroenterology : WJG·Gert Van AsschePaul Rutgeerts
Mar 8, 2013·World Journal of Gastroenterology : WJG·Vincenzo VillanacciGabrio Bassotti
Jul 13, 2014·Gastroenterología y hepatología·Montserrat AceitunoEsteve Maria
Jan 7, 2014·Biologics in Therapy·Pamela R Puthoor, Edwin F de Zoeten
Mar 1, 2008·Journal of Crohn's & Colitis·S P L TravisUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Sep 1, 2008·Journal of Crohn's & Colitis·Renzo CaprilliGiuseppe Frieri
Aug 27, 2009·Biologics : Targets & Therapy·Matteo BosaniGabriele Bianchi Porro
Oct 18, 2005·International Journal of Colorectal Disease·Stefan FarkasEdward K Geissler
Oct 29, 2013·Best Practice & Research. Clinical Gastroenterology·Francisco Portela, Paula Lago
Dec 22, 2015·Gastroenterology·Geoffrey C NguyenUNKNOWN Canadian Association of Gastroenterology
Sep 1, 2015·Journal of Digestive Diseases·Rosario FornaroElisa Caratto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.