Intravenous diazoxide in acute poststreptococcal glomerulonephritis.

The Journal of Pediatrics
E C KohautL L Hill

Abstract

Twenty-six patients with hypertension secondary to acute poststreptococcal glomerulonephritis were treated by the rapid intravenous infusion of diazoxide. The average pretreatment systolic pressure was 159 mm Hg. Five minutes after administration, the average systolic pressure was 122 mm Hg (a 23% reduction). The average initial diastolic pressure was 104 mm Hg, which fell 5 minutes after diazoxide injection to 71 mm Hg (a 32% reduction). No hypotensive episodes were noted. Occasional episodes of nausea occurred. Concentrations of blood glucose increased after administration of diazoxide; however, no values were above 155 mg/dl. Diazoxide appears to be a safe antihypertensive drug that is effective in the treatment of hypertension secondary to acute poststreptococcal glomerulonephritis.

References

Oct 1, 1974·Archives of Disease in Childhood·H R PowellD A McCredie
Jun 1, 1973·American Heart Journal·J P RadóT Halmos
Mar 1, 1973·Canadian Journal of Physiology and Pharmacology·P LarochelleR I Ogilvie
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Dec 1, 1971·Canadian Journal of Physiology and Pharmacology·R I Ogilvie, E Schlieper
Jun 30, 1961·Science·A A RUBINJ BLACK

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Citations

Aug 1, 1976·The Journal of Pediatrics·A W Pruitt, A Boles
Aug 1, 1977·Australian and New Zealand Journal of Medicine·K P Dawson, W W Richardson
May 1, 1979·The Journal of Pediatrics·J M LoggieA M Robson
Dec 1, 1977·Circulation·R C Boerth, W R Long

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