Intravenous diazoxide in treatment of hypertension associated with recent myocardial infarction.

British Medical Journal
K P O'BrienP M Taylor

Abstract

Twenty patients with blood pressure over 180/110 mm Hg one hour after admission to a coronary care unit with recent acute myocardial infarction were given intravenous diazoxide in a bolus of 300 mg. The average blood pressure before diazoxide was 194/122 mm Hg. Blood pressure fell considerably in all patients, though six patients required two injections. The average fall was 58 mm Hg systolic and 40 mm Hg diastolic. No patient became severely hypotensive. The heart rate increased by an average of 10 beats/min. In nine patients the electrocardiographic changes immediately after the administration of diazoxide suggested an increase in myocardial injury. Though none of the patients seemed to deteriorate clinically from the diazoxide the electrocardiographic changes suggested that the use of intravenous diazoxide to lower blood pressure in patients with acute myocardial infarction might possibly be deleterious.

References

Jun 1, 1972·Circulation·F NaeimS L Robbins
Dec 1, 1969·The American Journal of Cardiology·J C Scott, A W Cowley
Nov 1, 1963·American Heart Journal·G G ROWEC W CRUMPTON

❮ Previous
Next ❯

Citations

Apr 1, 1978·Journal of Clinical Pharmacology·A P Niarchos
Mar 26, 1979·European Journal of Clinical Pharmacology·A O Brubakk, J Bathen
Jan 1, 1988·Journal of General Internal Medicine·J B Reuler, G J Magarian
Oct 1, 1979·British Journal of Clinical Pharmacology·A M CummingsJ I Robertson
Jun 25, 2013·Pharmacology & Therapeutics·William A Coetzee
May 3, 1980·Lancet·L H Opie
Apr 1, 1979·British Journal of Clinical Pharmacology·P G Marx, D S Reid

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

JAMA : the Journal of the American Medical Association
G K KumarM A Razzaque
British Journal of Clinical Pharmacology
D M Chaput de SaintongeD W Vere
© 2022 Meta ULC. All rights reserved