PMID: 331925Sep 1, 1977Paper

Intravenous diazoxide therapy in hypertensive crisis

The American Journal of Cardiology
W J McDonaldB D Danielson

Abstract

Ninety-one doses of diazoxide were administered intravenously to 41 patients with hypertensive crises. Diastolic blood pressure was reduced from an average of 139 to 98 mm Hg within 10 minutes. On the basis of a retrospective analysis of the response of diastolic blood pressure, it was possible to determine within 10 minutes of injection whether a second dose would be required. Therapy was judged to be effective in 38 of 41 patients; 35 percent of injections were ineffective. Concomitant administration of furosemide was not shown to have a beneficial antihypertensive effect. Mean blood urea nitrogen was 59.5 mg/100 ml initially and was not significantly different 2 weeks after therapy. None of the patients demonstrated clinical evidence of diazoxide-induced deterioration of coronary circulation. Electrocardiograms obtained 2 weeks after diazoxide therapy failed to show evidence of new ischemic changes. Only 9 percent of patients complained of side effects, and these were transient and relatively innocuous. It is concluded that diazoxide is both safe and efficacious in the management of hypertensive crises.

References

Jun 1, 1976·Annals of Internal Medicine·S A KanadaD Wu
Dec 1, 1969·The American Journal of Cardiology·J C Scott, A W Cowley
Dec 1, 1969·The American Journal of Cardiology·W E MillerD G Vidt
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Nov 14, 1959·British Medical Journal·M HARINGTONJ McMICHAEL

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Citations

Jan 1, 1988·Journal of General Internal Medicine·J B Reuler, G J Magarian
Sep 1, 1989·Progress in Cardiovascular Diseases·M C Houston
Mar 1, 1979·The American Journal of Cardiology·C V Ram, N M Kaplan
Jul 1, 1980·Stroke; a Journal of Cerebral Circulation·G DieguezS Lluch
Jun 1, 1983·European Journal of Clinical Investigation·D I BarryT G Bolwig
Jul 1, 1980·Klinische Wochenschrift·A MeierF C Reubi
Jul 12, 2019·Brain : a Journal of Neurology·Mohammad Al-Mahdi Al-KaragholiMessoud Ashina

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