PMID: 9428898Jan 16, 1998Paper

Intravenous fibroblast growth factor penetrates the blood-brain barrier and protects hippocampal neurons against ischemia-reperfusion injury

Surgical Neurology
P CuevasG Giménez-Gallego

Abstract

Fibroblast growth factors (FGFs) play a role in neuronal survival after brain ischemia when administered intrace-rebrally. However, the clinical problems that chronic intracerebral infusion of FGFs involves may restrict its use. The purpose of this study was to analyze if FGFs administered intravenously might afford neuroprotection against transient brain ischemia in the light of new published data that suggest that these polypeptides cross the blood brain-barrier (BBB). The efficacy of acidic fibroblast growth factor (aFGF) treatment was analyzed in a gerbil model of 5 min forebrain ischemia followed by 7 days of reperfusion. Native and nonmitogenic aFGF was injected in gerbils as a bolus through a jugular vein at the onset of reperfusion. Control animals received in the same manner vehicle solution alone. Seven days later, neuroprotection was evaluated histologically. Penetration of the FGF across the BBB was assessed by autoradiographic studies in rats. For that purpose, we injected through the jugular vein 0.1 microgram of uniformly labeled native 14C-basic fibroblast growth factor (bFGF), 0.1 microgram of heat-denatured 14C-bFGF, or a coinjection of 14C-bFGF with a 900-fold excess of unlabeled bFGF. Two hours later, animal...Continue Reading

References

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Citations

Nov 15, 2007·Applied Microbiology and Biotechnology·Yadong HuangXiaokun Li
Jan 18, 2012·Neuroimmunomodulation·Michelle A EricksonWilliam A Banks
Dec 21, 2007·Lancet Neurology·Edward NeuweltLester R Drewes
Aug 31, 2014·Brain, Behavior, and Immunity·W A Banks
Apr 26, 2001·Neurological Research·P Cuevas, F Carceller
Mar 24, 2020·Molecular Reproduction and Development·Susanta K BehuraThomas E Spencer
May 28, 2019·Nature Reviews. Endocrinology·William A Banks
Mar 6, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Narjes ShahsavaniSoheila Karimi-Abdolrezaee
May 18, 2021·Frontiers in Physiology·Laura Gerosa, Giovanni Lombardi

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