Intravenous Fish Oil and Pediatric Intestinal Failure-Associated Liver Disease: Changes in Plasma Phytosterols, Cytokines, and Bile Acids and Erythrocyte Fatty Acids.

JPEN. Journal of Parenteral and Enteral Nutrition
Kara L CalkinsRobert Venick

Abstract

Soybean oil (SO) emulsions are associated with intestinal failure-associated liver disease (IFALD); fish oil (FO) emulsions are used to treat IFALD. SO and FO differ with respect to their fatty acid and phytosterol content. In children with IFALD whose SO was replaced with FO, we aimed to (1) quantify changes in erythrocyte fatty acids and plasma phytosterols, cytokines, and bile acids and (2) correlate these changes with direct bilirubin (DB). This study enrolled IFALD children who received 6 months of FO. Blood samples were collected prior to FO, and after 2 weeks and 3 and 6 months of FO. The primary outcome was 3-month vs baseline biomarker concentrations. At study initiation, the median patient age was 3 months (interquartile range, 3-17 months), and mean ± standard deviation DB was 5.6 ± 0.7 mg/dL (n = 14). Cholestasis reversed in 79% of subjects. Eicosapentaenoic and docosahexaenoic acid was greater than baseline (P < .001, all time points). Linoleic and arachidonic acid and sitosterol and stigmasterol were less than baseline (P < .05, all time points). Three- and 6-month interleukin-8 (IL-8) and total and conjugated bile acids were less than baseline (P < .05). Baseline IL-8 was correlated with baseline DB (r = 0.71, P ...Continue Reading

Associated Clinical Trials

References

Jun 11, 2002·Annual Review of Nutrition·Richard E Ostlund
Dec 2, 2004·Journal of Pediatric Gastroenterology and Nutrition·Valerio NobiliFabrizio De Benedetti
Jul 5, 2005·The American Journal of Cardiology·Klaus von BergmannDieter Lütjohann
Apr 25, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Terufumi YokoyamaHiromi Ishibashi
Aug 11, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Naoko KobayashiWilliam J Aronson
Oct 3, 2008·The Journal of Nutritional Biochemistry·Nerea Pérez-EcharriMaría J Moreno-Aliaga
Oct 29, 2008·Journal of Pediatric Gastroenterology and Nutrition·P PianeseG Corso
Nov 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karim C El KasmiRonald J Sokol
Dec 27, 2011·Journal of Pediatric Gastroenterology and Nutrition·Annika KurvinenMikko P Pakarinen
May 15, 2012·The Journal of Pediatrics·Robert H SquiresUNKNOWN Pediatric Intestinal Failure Consortium
Jul 31, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Kara L CalkinsRobert S Venick
Oct 5, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Brian T KalishMark Puder
Oct 11, 2013·Science Translational Medicine·Karim C El KasmiRonald J Sokol
Mar 11, 2016·JPEN. Journal of Parenteral and Enteral Nutrition·Prathima NandivadaMark Puder

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