Intravenous glucose tolerance test-derived glucose effectiveness in bulimia nervosa

Metabolism: Clinical and Experimental
A TaniguchiI Nagata

Abstract

The aim of the present study was to estimate insulin secretion, insulin sensitivity (SI), and glucose effectiveness at basal insulin (SG) in subjects with bulimia nervosa. Eight bulimic patients and eight age-, body mass index-, and sex-matched healthy control subjects without a family history of diabetes were studied. The subjects all had normal glucose tolerance. They underwent a modified frequently sampled intravenous glucose tolerance test; glucose (300 mg/kg body weight) was administered, and insulin (4 mU/kg body weight/min) was infused from 20 to 25 minutes after administration of glucose. SI and SG were estimated by Bergman's minimal model method. Basal insulin (27 +/- 3 v 45 +/- 3 pmol/L) was significantly lower in bulimic patients than in normal controls (P < .05), but basal glucose was similar between the two groups (4.5 +/- 0.1 v 4.9 +/- 0.1 mmol/L, P > .05). The glucose disappearance rate (KG) and acute insulin response to glucose estimated by the intravenous glucose tolerance test (AIR(glucose)) were similar between the two groups (KG, 1.35 +/- 0.29 v 2.20 +/- 0.21 min(-1), P > .05; AIR(glucose), 2,920 +/- 547 v 2,368 +/- 367 pmol/L x min, P > .05). No significant difference was observed in SI between the two grou...Continue Reading

Citations

Mar 22, 2000·Metabolism: Clinical and Experimental·T KonradP Neuhaus
Sep 6, 2002·Physiology & Behavior·Kelly A GendallCynthia M Bulik
Jun 1, 1997·Eating and Weight Disorders : EWD·M R LetiexheP J Lefèbvre
Nov 21, 2007·Expert Review of Molecular Diagnostics·Kent A HatchDustin Williams
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Palmiero MonteleoneMario Maj

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