Intravenous heroin self-administration decreases GABA efflux in the ventral pallidum: an in vivo microdialysis study in rats

The European Journal of Neuroscience
Stéphanie Caillé, Loren H Parsons

Abstract

Several lines of evidence suggest that opiate-induced disinhibition of the ventral pallidum participates in the mediation of opiate reward, though direct in vivo evidence to support this hypothesis has been lacking. The present experiment tested this hypothesis by investigating alterations in ventral pallidal amino acid efflux using in vivo microdialysis during ongoing intravenous heroin self-administration in rats. Concentrations of the inhibitory amino acid GABA in ventral pallidal dialysates were significantly reduced within the first 10 min of heroin self-administration (0.02 mg per infusion; FR-1), and remained approximately 65% of presession baseline levels for the remainder of the 3-h self-administration session. Dialysate glutamate levels were unaltered during the first hour of heroin intake but significantly increased to a stable level of approximately 120% presession values during the subsequent 2 h of self-administration. Thus, heroin self-administration is associated with both decreased GABA efflux and a late phase increase in glutamate efflux in the ventral pallidum. These observations are consistent with the hypothesis that heroin self-administration results in a disinhibition and/or excitation of the ventral pall...Continue Reading

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Citations

May 4, 2012·Psychopharmacology·Heidi KemppainenKalervo Kiianmaa
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stéphanie Caillé, Loren H Parsons
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John McDaidT Celeste Napier
Jun 22, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas J MartinJames E Smith
Sep 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Peter W Kalivas, Charles O'Brien
Jan 16, 2010·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Heidi KemppainenKalervo Kiianmaa
Feb 7, 2008·The Journal of Pharmacology and Experimental Therapeutics·Mary M Torregrossa, Peter W Kalivas
May 9, 2012·Biochemical and Biophysical Research Communications·W WuS B Li
Jul 30, 2011·Pharmacology & Therapeutics·Antonia Serrano, Loren H Parsons
Oct 13, 2009·Hormones and Behavior·Marilyn E Carroll, Justin J Anker
Oct 29, 2008·Behavioural Brain Research·Kyle S SmithKent C Berridge
Oct 30, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·José M OlivaJorge Manzanares
Oct 12, 2007·Pharmacology, Biochemistry, and Behavior·Mary M Torregrossa, Peter W Kalivas
Nov 26, 2015·Frontiers in Neuroscience·Manoranjan S D'Souza
Aug 21, 2007·Biochemical Pharmacology·Justin T Gass, M Foster Olive
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Apr 11, 2015·Progress in Neurobiology·David H RootT Celeste Napier
Dec 9, 2009·Neurotoxicology·C PopeL Parsons
Jun 28, 2018·Addiction Biology·Maria A De LucaGaetano Di Chiara

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