Intravenous Hydralazine in Hospitalized Children and Adolescents with Hypertension

The Journal of Pediatrics
Joseph T FlynnEric M Harvey

Abstract

To explore the efficacy and safety of intravenous (IV) hydralazine in hospitalized children with hypertension. Data were retrospectively collected on hospitalized children treated with IV hydralazine. Percent changes in blood pressure (BP) were calculated, and linear regression was used to investigate associations between BP change and pertinent clinical and demographic variables. Bivariate logistic regression was used to investigate associations between the same covariates and the outcomes of ideal clinical response (ICR), a 10%-25% reduction in mean arterial pressure (MAP), and excess response (ER), a 25% reduction in MAP. A total of 141 initial doses of IV hydralazine (median dose, 0.10 mg/kg [IQR, 0.09-0.11; range, 0.02-0.37]) were analyzed. Median age was 8 years (IQR, 2-15; range, 0-24); most patients had renal disease, malignancy, or were organ transplant recipients. The mean MAP reduction was 19% ± 12%. An ICR occurred in 66 patients (47%). Higher initial MAP and increased hydralazine dose were associated with greater percentage decrease in MAP. No association was found between ICR and the covariates of interest; higher initial MAP was associated with greater odds of ICR. ER occurred in 44 children (31%). Among this gro...Continue Reading

References

Sep 1, 1992·Archives of Disease in Childhood·J E DealM J Dillon
Apr 1, 1969·The Journal of Pediatrics·J M Loggie
Aug 3, 2004·Pediatrics·UNKNOWN National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents
Apr 1, 2005·Current Opinion in Pediatrics·Hiren P Patel, Mark Mitsnefes
Oct 8, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Joseph T Flynn, Kjell Tullus
Feb 21, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Julie OstryeIbrahim F Shatat
Jun 9, 2014·Current Hypertension Reports·Rossana Baracco, Tej K Mattoo

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Citations

Oct 23, 2015·The Journal of Pediatrics·Donald L Batisky
Aug 5, 2020·The Journal of Clinical Hypertension·Kathryn R KocherLilliana Michelle Gomez Mendez
Jan 11, 2020·Paediatric Drugs·Rossana Baracco
Aug 23, 2017·Pediatrics·Joseph T FlynnUNKNOWN SUBCOMMITTEE ON SCREENING AND MANAGEMENT OF HIGH BLOOD PRESSURE IN CHILDREN

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