Intravenous ibandronate rapidly reduces pain, neurochemical indices of central sensitization, tumor burden, and skeletal destruction in a mouse model of bone cancer.

Journal of Pain and Symptom Management
Kyle G HalvorsonPatrick W Mantyh

Abstract

Over half of all chronic cancer pain arises from metastases to bone and bone cancer pain is one of the most difficult of all persistent pain states to fully control. Currently, bone pain is treated primarily by opioid-based therapies, which are frequently accompanied by significant unwanted side effects. In an effort to develop nonopioid-based therapies that could rapidly attenuate tumor-induced bone pain, we examined the effect of intravenous administration of the bisphosphonate, ibandronate, in a mouse model of bone cancer pain. Following injection and confinement of green fluorescent protein-transfected murine osteolytic 2472 sarcoma cells into the marrow space of the femur of male C3H/HeJ mice, ibandronate was administered either as a single dose (300 microg/kg), at Day 7 post-tumor injection, when tumor-induced bone destruction and pain were first evident, or in three consecutive doses (100 microg/kg/day) at Days 7, 8, and 9 post-tumor injection. Intravenous ibandronate administered once or in three consecutive doses reduced ongoing and movement-evoked bone cancer pain-related behaviors, neurochemical markers of central sensitization, tumor burden, and tumor-induced bone destruction. These results support limited clinical ...Continue Reading

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Citations

Mar 22, 2016·Journal of Bone Oncology·Gerrit Steffen MaierAndreas Alois Kurth
Oct 9, 2015·Yonsei Medical Journal·Yoon Sok ChungTaeyong Lee
May 7, 2016·Pain Management·David K Lam
Mar 26, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Brian L Schmidt
Sep 5, 2015·Cancer Growth and Metastasis·Lauren M SloskyTodd W Vanderah
Jul 28, 2019·British Journal of Pharmacology·Thomas M Tzschentke

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