PMID: 8955465Nov 1, 1996Paper

Intravenous immune globulin in neonatal immune hemolytic disease: does it reduce hemolysis?

Acta Paediatrica
C HammermanD K Stevenson

Abstract

We studied the effect of intravenous immune globulin (IVIG) on hemolysis in term, hyperbilirubinemic, Coomb's positive infants utilizing measurement of carboxyhemoglobin fraction corrected for inhaled carbon monoxide (COHbc), a sensitive indicator of hemolysis. COHbc values were determined before and after IVIG infusion. In those babies who responded with a decrease in serum total bilirubin (n = 19), no exchange transfusions were required and COHbc levels decreased significantly by 24 h post-IVIG from 1.37 +/- 0.31 to 1.12 +/- 0.26% tHb (p < 0.0001). There were no corresponding decreases in COHbc levels (1.989 +/- 0.54 to 1.82 +/- 0.48% tHb; p > 0.05) among those whose serum bilirubin levels did not decrease in response in to IVIG (n = 7), and all of these infants required exchange transfusions. Furthermore, the extent of the decrease in COHbc was related to the degree of decrease in serum bilirubin levels, such that the percentage decrease of bilirubin at 24 h was directly correlated with the percentage decrease of COHbc at 24 h (p = 0.007). We conclude that IVIG, when successful, inhibits hemolysis in these infants.

Citations

Jul 26, 2008·Journal of the Medical Library Association : JMLA·Sandra MartinWilliam Walsh
Jul 10, 2009·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·F MonpouxP Boutté
Aug 16, 2014·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·A CorteyY Aujard
Mar 7, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·M KaplanR Regev
Dec 7, 2006·Clinics in Perinatology·Jon F Watchko
Jan 7, 2011·The Journal of Obstetrics and Gynaecology Research·Yunhui GongRong Zhou
Nov 5, 2003·Expert Opinion on Pharmacotherapy·Thor Willy Ruud Hansen
Aug 31, 1999·The Annals of Pharmacotherapy·J A HaskinD U Blank
Dec 13, 2002·Journal of Perinatology : Official Journal of the California Perinatal Association·K ArefL P Brion
Jul 20, 2019·Fetal and Pediatric Pathology·Birol Karabulut, Baran Cengiz Arcagok
Jul 26, 2002·The Cochrane Database of Systematic Reviews·G S Alcock, H Liley
Mar 20, 2018·The Cochrane Database of Systematic Reviews·Carolien ZwiersHelen G Liley

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