Intravenous immunoglobulin and idiopathic secondary recurrent miscarriage: a multicentered randomized placebo-controlled trial.

Human Reproduction
M D StephensonChuanhong Liao

Abstract

Idiopathic secondary recurrent miscarriage may be associated with an abnormal maternal immune response to subsequent pregnancies. Intravenous immunoglobulin (IVIG) has been studied in randomized controlled trials (RCTs) with conflicting results. Therefore, a definitive trial was proposed. We conducted an investigator-initiated, multicentered, randomized, double-blinded, placebo-controlled trial comparing IVIG with saline in women with idiopathic secondary recurrent miscarriage, defined as a history of at least one prior ongoing pregnancy followed by three or more consecutive unexplained miscarriages. Subjects received either IVIG 500 mg/kg or the equivalent volume of normal saline. Preconception infusions were administered 14-21 days from the projected next menstrual period. With documentation of pregnancy, the subject received the same infusion every 4 weeks until 18-20 weeks of gestation. The primary outcome was an ongoing pregnancy of at least 20 weeks of gestation. A total of 82 patients enrolled, of whom 47 had an index pregnancy. All ongoing pregnancies resulted in live births. Therefore, the live birth rates were 70% (16/23) in the IVIG group and 63% (15/24) in the control group (P = 0.760); odds ratio (OR) 1.37 [95% con...Continue Reading

References

Jul 28, 1988·The New England Journal of Medicine·A J WilcoxB C Nisula
Mar 1, 1984·Journal of Epidemiology and Community Health·E Roman
May 20, 1998·Biochemical and Biophysical Research Communications·G ReinhardA V Ruecker
Jan 13, 2000·Fertility and Sterility·K J LimI D Cooke
May 5, 2000·The Cochrane Database of Systematic Reviews·J R Scott
Jul 10, 2003·Fertility and Sterility·Rebecca L DubowyHarvey J Kliman
Dec 15, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·B HuttonM Walker
Feb 17, 2007·Clinical Obstetrics and Gynecology·Mary Stephenson, William Kutteh
Dec 1, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·J M SchutteUNKNOWN Netherlands Maternal Mortality Committee

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Citations

Apr 13, 2011·Human Reproduction Update·Henriette Svarre Nielsen
Sep 23, 2014·Cellular & Molecular Immunology·Hilary S GammillJ Lee Nelson
May 25, 2012·Ocular Immunology and Inflammation·Denis WakefieldPeter McCluskey
Apr 22, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tinnakorn ChaiworapongsaSonia S Hassan
Dec 7, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ivana Bozic AnticSvetozar Damjanovic
Feb 6, 2016·American Journal of Reproductive Immunology : AJRI·Arsène MekinianMarie Bornes
Feb 5, 2014·Obstetrics and Gynecology Clinics of North America·Ole B Christiansen
Feb 5, 2014·Obstetrics and Gynecology Clinics of North America·Paul R Brezina, William H Kutteh
Sep 10, 2013·Psychosomatics·Gagandeep KaurSteven Lippmann
Sep 10, 2013·Fertility and Sterility·Kinue KatanoMayumi Sugiura-Ogasawara
Oct 30, 2015·American Journal of Reproductive Immunology : AJRI·Sung Ki LeeJoanne Kwak-Kim
Dec 27, 2011·Journal of Reproductive Immunology·A S BansalM Y Thum
Sep 26, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Nina RogenhoferChristian J Thaler
May 2, 2014·Immunologic Research·Rakesh PopliDavid B Miklos
Aug 1, 2012·Reproduction in Domestic Animals = Zuchthygiene·D F Antczak
Jun 1, 2011·American Journal of Reproductive Immunology : AJRI·Edward E WingerMohamed Taranissi
Jul 9, 2011·American Journal of Reproductive Immunology : AJRI·David A Clark
Mar 3, 2012·American Journal of Reproductive Immunology : AJRI·Kenneth D BeamanAlice Gilman-Sachs
Jul 19, 2012·American Journal of Reproductive Immunology : AJRI·Michael R VirroJane L Reed
Mar 13, 2014·American Journal of Reproductive Immunology : AJRI·Rocio Ramos-MedinaSilvia Sánchez-Ramón
Apr 15, 2015·Autoimmunity Reviews·Nurit Katz-AgranovGisele Zandman-Goddard
Apr 26, 2016·American Journal of Reproductive Immunology : AJRI·Paola TriggianeseRoberto Perricone
Mar 15, 2016·American Journal of Hematology·Eric M AmmannElizabeth A Chrischilles
Oct 19, 2016·La Revue de médecine interne·A MekinianO Fain
Apr 22, 2017·Clinical and Experimental Reproductive Medicine·Nayoung SungUNKNOWN IVIG Task Force, Korean Society for Reproductive Immunology
Apr 18, 2013·British Journal of Hospital Medicine·K McNameeR G Farquharson
Apr 1, 2018·Acta Obstetricia Et Gynecologica Scandinavica·Emma Rasmark RoepkeAnnika Strandell
Jul 10, 2018·American Journal of Reproductive Immunology : AJRI·Kahinho P MuyayaloAi-Hua Liao
Nov 22, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·P P SmithT J Clark
Dec 18, 2018·The Cochrane Database of Systematic Reviews·Aleena M WojcieszekVicki Flenady
Nov 22, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·Ob ChristiansenH S Nielsen
Oct 22, 2014·The Cochrane Database of Systematic Reviews·Luchin F WongJames R Scott
Jul 1, 2014·Current Opinion in Obstetrics & Gynecology·William H Kutteh

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