Intravenous immunoglobulin attenuates airway inflammation through induction of forkhead box protein 3-positive regulatory T cells

The Journal of Allergy and Clinical Immunology
A H MassoudBruce Mazer

Abstract

Intravenous immunoglobulin (IVIG) is a frequently used disease-modifying therapy for a large spectrum of autoimmune and inflammatory conditions, yet its mechanisms of action are incompletely understood. Using a robust murine model of antigen-driven allergic airways disease, we have demonstrated that IVIG markedly improves ovalbumin (OVA)-induced airway hyperresponsiveness characterized by 4- to 6-fold enhancement in regulatory T (Treg) cells in pulmonary and associated lymphoid tissues. We sought to determine whether IVIG induces antigen-specific Treg cells and to address cellular interactions that lead to induction of Treg cells by IVIG. C57Bl/6 mice were sensitized and challenged by means of intranasal OVA exposure. IVIG or albumin control was administered 24 hours before challenge. Treg cells were tracked by using green fluorescent protein (GFP)-forkhead box protein 3 (Foxp3) knock-in reporter mice (Foxp3(GFP)), and Treg cell and dendritic cell (DC) phenotypes and activities were elucidated by using coculture and flow cytometry. IVIG therapy of OVA-sensitized and OVA-challenged mice induced antigen-specific forkhead box protein 3 (Foxp3)-positive Treg cells from non-Treg cell precursors. The induced Treg cells home specifica...Continue Reading

References

May 5, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M Ballow
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ralph Marvin Steinman, Michel C Nussenzweig
Dec 5, 2002·The Journal of Allergy and Clinical Immunology·Christine McCuskerBruce Mazer
May 3, 2003·Annals of the New York Academy of Sciences·Ralph M SteinmanMichel Nussenzweig
Dec 12, 2003·Journal of Pediatric Hematology/oncology·Andrew R Crow, Alan H Lazarus
Apr 20, 2004·Current Opinion in Allergy and Clinical Immunology·Christine T McCusker
Aug 11, 2005·Current Allergy and Asthma Reports·Carsten B Schmidt-Weber, Kurt Blaser
Apr 4, 2006·The Journal of Allergy and Clinical Immunology·Jordan S OrangeUNKNOWN Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology
May 23, 2006·Nature Medicine·Vinayakumar SiragamAlan H Lazarus
Jan 4, 2007·The Journal of Experimental Medicine·Tomoki ItoMichel Gilliet
Jan 18, 2007·The Journal of Experimental Medicine·Falk Nimmerjahn, Jeffrey V Ravetch
Feb 27, 2007·The Journal of Allergy and Clinical Immunology·Mübeccel Akdis, Cezmi A Akdis
May 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Falk NimmerjahnJeffrey V Ravetch
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aharon KesselElias Toubi
Mar 29, 2008·Annual Review of Immunology·Falk Nimmerjahn, Jeffrey V Ravetch
Nov 28, 2008·Proceedings of the National Academy of Sciences of the United States of America·Robert M AnthonyJeffrey V Ravetch
Apr 21, 2009·Current Opinion in Immunology·Derk AmsenRichard A Flavell
Jun 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pádraic J DunneKingston H G Mills
Jul 28, 2009·Journal of Thrombosis and Haemostasis : JTH·A R CrowA H Lazarus
Sep 16, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Miao-Tzu HuangBor-Luen Chiang
Oct 23, 2009·The New England Journal of Medicine·Eva d'HennezelCiriaco A Piccirillo
May 19, 2010·Journal of Clinical Immunology·Robert M Anthony, Jeffrey V Ravetch
Jun 8, 2010·The European Respiratory Journal·J A PrestonP M Hansbro
Sep 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hui HuangJohn R Gordon
Oct 15, 2010·Molecular Biology of the Cell·Keisuke TabataTamotsu Yoshimori
Jan 25, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G N KaufmanB D Mazer
Feb 1, 2011·The Journal of Allergy and Clinical Immunology·Brian P VickeryA Wesley Burks
Jun 21, 2011·Nature·Robert M AnthonyJeffrey V Ravetch

❮ Previous
Next ❯

Citations

Feb 9, 2013·The Journal of Clinical Investigation·Lauren E MaysMichael S D Kormann
Oct 9, 2013·Critical Reviews in Immunology·Charles B SmarrStephen D Miller
Jun 3, 2014·Journal of Translational Medicine·Huiyun ZhangShaoheng He
Sep 3, 2013·Clinical and Experimental Medicine·Miglena G PrabagarYoung-Sun Kang
May 31, 2014·Current Opinion in Pharmacology·Federica PettaVincenzo Casolaro
Apr 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Benjamin M FiebigerJeffrey V Ravetch
Oct 11, 2014·Arthritis & Rheumatology·Jean-François SéïtéJacques-Olivier Pers
Sep 5, 2012·Autoimmunity Reviews·Leslie P CousensAnne S De Groot
Nov 12, 2013·The Journal of Allergy and Clinical Immunology·Amir H MassoudBruce D Mazer
Jan 29, 2013·The Journal of Allergy and Clinical Immunology·Bruce S BochnerFred Finkelman
Feb 5, 2013·The Journal of Allergy and Clinical Immunology·Javier ChinenWilliam T Shearer
Oct 22, 2013·The Journal of Allergy and Clinical Immunology·Jean-François SéïtéSophie Hillion
Mar 8, 2013·The Journal of Allergy and Clinical Immunology·Amir H MassoudBruce D Mazer
Mar 8, 2013·The Journal of Allergy and Clinical Immunology·Jamma TrinathJagadeesh Bayry
Nov 19, 2014·Seminars in Immunopathology·Sri Ramulu ElluruJagadeesh Bayry
Apr 28, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Chong ShenCharles Pilette
Jul 19, 2016·Expert Opinion on Drug Metabolism & Toxicology·Livia DézsiLászló Vécsei
Nov 25, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Di XueBruce D Mazer
Feb 22, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amir H MassoudBruce D Mazer
Jul 10, 2018·American Journal of Reproductive Immunology : AJRI·Kahinho P MuyayaloAi-Hua Liao
Sep 16, 2017·Allergy, Asthma & Immunology Research·Joo Hee KimHae Sim Park
May 9, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Angela S W TjonJaap Kwekkeboom
Dec 14, 2012·Expert Review of Respiratory Medicine·Joseph I Székely, Ágnes Pataki
Oct 23, 2014·Current Opinion in Allergy and Clinical Immunology·Mark Ballow
Apr 10, 2020·Frontiers in Immunology·Elizabeth A FitzpatrickS E Strome
Dec 23, 2016·Frontiers in Immunology·Di XueBruce D Mazer
Jul 2, 2017·International Immunology·Caroline GaleottiJagadeesh Bayry
Mar 29, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B Mazer
Jan 12, 2021·Journal of Immunology Research·Xiuhua Yang, Tao Meng
May 7, 2021·Frontiers in Immunology·Marieme DembeleBruce D Mazer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
G N KaufmanBruce Mazer
Immunology Letters
Dominic Paquin ProulxRenée Bazin
Proceedings of the National Academy of Sciences of the United States of America
Robert M AnthonyJeffrey V Ravetch
© 2021 Meta ULC. All rights reserved