Intravenous immunoglobulin-based immunotherapy: an arsenal of possibilities for patients and science

Immunotherapy
Beatrix KotlanFrancesco M Marincola

Abstract

The use of intravenous immunoglobulin (IVIG) concentrated from pooled healthy donors' plasma has gained increasing popularity. IVIG therapy has become important as a replacement therapy in primary and acquired humoral immunodeficiencies, and it has been extended to autoimmune, neurodegenerative and inflammatory conditions and transplantation therapy. Recurrent pregnancy failure and cancer are rather new platforms, where IVIG has shown its beneficial effects. This manuscript is focused on these two off-labelled usages. The immunomodulatory mechanisms of IVIG therapy appear as a coordinated orchestration of different functions, resulting in a synergistic effect. Treatment monitoring and detailed molecular analyses reveal how such treatments may interfere with disease pathogenesis. These finding may foster the development of novel therapeutic and/or preventive strategies. Studying this field with bidirectional bench-to-bedside and bedside-to-bench approaches fit well into 'the two-way road' paradigm of translational medicine.

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Citations

Aug 21, 2013·Future Virology·Chandran RamakrishnaEdouard M Cantin
Jun 21, 2013·Journal of the Peripheral Nervous System : JPNS·Marzieh NiknamiJohn D Pollard
Feb 2, 2016·Biochimica Et Biophysica Acta·Lucas D BreenDjuro Josić
May 4, 2016·Immunotherapy·Angel L CorbíAngeles Domínguez-Soto
Jan 24, 2018·Behavioural Neurology·Chandran RamakrishnaEdouard M Cantin
Jan 14, 2016·The Cochrane Database of Systematic Reviews·Lu LiChi Chiu Wang
Oct 19, 2017·Human Antibodies·Ivan BabicSantosh Kesari

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Methods Mentioned

BETA
gel filtration
phage display
phage-display

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