Intravenous immunoglobulin counteracts oxidative stress in Kawasaki disease.

Pediatric Cardiology
Kazunari KanekoShoji Tsuji

Abstract

Oxidative stress (OS) appears to play a pivotal role in many medical conditions. This study aimed to investigate whether OS is associated with Kawasaki disease (KD) or not, and if so, then to determine whether the mechanism of intravenous immunoglobulin therapy (IVIG) is associated with scavenging reactive oxygen species. Results show a significant difference between patients with KD and those with febrile illnesses (p = 0.018) in terms of OS, as assessed by the d-ROMs/BAP ratio, an arbitrary index comprising derivatives of reactive oxygen metabolites (d-ROMs) relative to a biologic antioxidant potential (BAP). Furthermore, children with KD had a significantly decreased d-ROMs/BAP ratio after IVIG (p = 0.011). Interestingly, the d-ROMs/BAP ratio decreased in 12 of 14 patients with KD who defervesced after IVIG, whereas all but one patient who did not defervesce showed an increase in this ratio. In conclusion, OS plays an important role in the pathogenesis of acute KD. Because IVIG therapy relieves OS by augmenting BAP, an assessment of OS in the acute phase of KD may be useful for early recognition of the necessity to perform additional IVIG treatment. Further study to elucidate this point would be worthwhile.

References

Feb 6, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Esther Granot, Ron Kohen
Aug 11, 2004·Lancet·Jane C Burns, Mary P Glodé
Nov 21, 2008·European Journal of Pediatrics·Ken YoshimuraKazunari Kaneko
May 14, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Shinichi TakatsukiTsutomu Saji
Nov 4, 2009·Clinical and Experimental Immunology·A DurandyR Rieben
Jul 24, 2010·Molecules and Cells·Michael J Morgan, Zheng-Gang Liu

❮ Previous
Next ❯

Citations

May 15, 2012·Antioxidants & Redox Signaling·Elisabetta StrafaceDonatella Pietraforte
Sep 17, 2013·Journal of the American Academy of Dermatology·Stephanie BayersAmy S Paller
Sep 17, 2013·Journal of the American Academy of Dermatology·Stephanie BayersAmy S Paller
Jun 13, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ken-Pen WengLuo-Ping Ger
Jul 5, 2015·Clinical Reviews in Allergy & Immunology·Priscilla H Wong, Kevin M White
Dec 31, 2019·Oxidative Medicine and Cellular Longevity·Martha A Sánchez-Rodríguez, Víctor Manuel Mendoza-Núñez
Dec 6, 2017·International Journal of Rheumatic Diseases·Mindy S Lo, Jane W Newburger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.