PMID: 8607936Dec 1, 1995Paper

Intravenous immunoglobulin for treatment of recurrent pregnancy loss

American Journal of Reproductive Immunology : AJRI
C B CoulamM Bustillo

Abstract

Efficacy of immunotherapy for treatment of recurrent spontaneous abortion (SA) has been controversial. The low treatment effect of white blood cell immunization lead to investigations of alternative treatments including intravenous (i.v.) immunoglobulin (Ig). To evaluate the efficacy of IVIg for treatment of recurrent SA, a prospective, randomized, double blinded, placebo-controlled trial was performed. Ninety-five women experiencing two or more consecutive spontaneous abortions, with no known cause were randomized and received either IVIg 500 mg/kg/month or placebo (albumin). Of 95 women participating in the study, 47 received IVIg and 48 received placebo. Medication was discontinued in 34 women who failed to conceive within four cycles. The remaining 61 women achieved pregnancy. Pregnancy outcomes included 29 deliveries and 32 recurrent SA. Among women delivering live births 18 (62%) received IVIg and 11 (38%) received placebo. By contrast, 21 (66%) women experiencing recurrent SAs received placebo and 11 (34%) received IVIg. Among 61 women who conceived, 29 received IVIg and 32 received placebo. Of the 29 women who conceived and received IVIg, 18 (62%) delivered live births and 11 (38%) experienced recurrent SA. Of 32 women ...Continue Reading

References

Apr 1, 1977·American Journal of Obstetrics and Gynecology·B J PolandB K Trimble
May 1, 1992·Human Reproduction·O B ChristiansenN Grunnet
Feb 16, 1991·Lancet·G Mueller-EckhardtB Polten
Mar 30, 1991·Lancet·D M Jenkins
Mar 15, 1989·Annals of Internal Medicine·A ParkeM Ballow
Nov 1, 1989·American Journal of Reproductive Immunology : AJRI·J A McIntyreW P Faulk
Jul 1, 1989·British Journal of Haematology·A C Newland
Jan 1, 1989·Vox Sanguinis·G Mueller-EckhardtC Mueller-Eckhardt
Dec 15, 1988·Annals of Internal Medicine·A FrancoisC Jacquot
Aug 1, 1988·American Journal of Epidemiology·H A RischA B Miller
Jul 1, 1988·British Journal of Obstetrics and Gynaecology·F ParazziniG B Candiani
Aug 1, 1983·Molecular Immunology·J KulicsJ Gergely
Dec 1, 1994·American Journal of Reproductive Immunology : AJRI·C B Coulam

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Citations

Jul 11, 2009·Clinical Reviews in Allergy & Immunology·Shaye KivityYehuda Shoenfeld
Sep 15, 2004·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Feb 24, 2000·Fertility and Sterility·M OgasawaraK Suzumori
Jan 9, 1998·Journal of Reproductive Immunology·W H Kutteh
Jun 24, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Mamoru MorikawaHisanori Minakami
May 8, 2003·American Journal of Reproductive Immunology : AJRI·Olga GraphouMarighoula Varla-Leftherioti
Jan 1, 1995·American Journal of Reproductive Immunology : AJRI·C B CoulamK D Beaman
Apr 1, 1996·American Journal of Reproductive Immunology : AJRI·C B CoulamD A Clark
Apr 1, 1997·American Journal of Reproductive Immunology : AJRI·C B Coulam, D A Clark
Feb 12, 1998·American Journal of Reproductive Immunology : AJRI·C A Mullen
Mar 20, 1998·American Journal of Reproductive Immunology : AJRI·D A Clark, S Daya
Mar 20, 1998·American Journal of Reproductive Immunology : AJRI·S DayaD A Clark
Apr 2, 1999·American Journal of Reproductive Immunology : AJRI·W H KuttehR Silver
Jan 6, 2000·American Journal of Reproductive Immunology : AJRI·A S KaiderR G Roussev
Oct 30, 2015·American Journal of Reproductive Immunology : AJRI·Sung Ki LeeJoanne Kwak-Kim
Jul 28, 2012·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Sep 26, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Nina RogenhoferChristian J Thaler
Jun 17, 2009·American Journal of Reproductive Immunology : AJRI·Shrimati Shetty, Kanjaksha Ghosh
Oct 9, 2009·American Journal of Reproductive Immunology : AJRI·Shigeki ShimadaHideto Yamada
Dec 15, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·B HuttonM Walker
Mar 3, 2012·American Journal of Reproductive Immunology : AJRI·Leif MatthiesenSurendra Sharma
Mar 14, 2013·American Journal of Reproductive Immunology : AJRI·Rocío Ramos-MedinaSilvia Sánchez-Ramón
Nov 22, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·Ob ChristiansenH S Nielsen
Mar 13, 2014·American Journal of Reproductive Immunology : AJRI·Rocio Ramos-MedinaSilvia Sánchez-Ramón
Mar 8, 2005·Best Practice & Research. Clinical Obstetrics & Gynaecology·T Flint Porter, James R Scott
Sep 22, 2012·ISRN Obstetrics and Gynecology·Hideto YamadaShigeki Shimada
Apr 15, 2015·Autoimmunity Reviews·Nurit Katz-AgranovGisele Zandman-Goddard
Oct 12, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·L Regan, R Rai
Apr 26, 2016·American Journal of Reproductive Immunology : AJRI·Paola TriggianeseRoberto Perricone
Mar 15, 2016·American Journal of Hematology·Eric M AmmannElizabeth A Chrischilles
Apr 22, 2017·Clinical and Experimental Reproductive Medicine·Nayoung SungUNKNOWN IVIG Task Force, Korean Society for Reproductive Immunology
Aug 4, 2004·Journal of Reproductive Immunology·Ole B ChristiansenBjorn Pedersen
Apr 26, 2006·American Journal of Reproductive Immunology : AJRI·Beatrix KotlanGyozo Petranyi
Sep 22, 1998·Scandinavian Journal of Immunology·T E MollnesR Perricone
Jul 10, 2018·American Journal of Reproductive Immunology : AJRI·Kahinho P MuyayaloAi-Hua Liao

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