Intravenous immunoglobulin improves sepsis-induced coagulopathy: A retrospective, single-center observational study

Journal of Critical Care
Hiroyasu IshikuraAkira Murai

Abstract

Inflammation and coagulation are closely interrelated processes in the pathogenesis of sepsis. This study aimed to determine whether intravenous immunoglobulin (IVIg) could improve the hyperinflammatory state and coagulation/fibrinolysis abnormalities in patients with sepsis. Forty-one patients with sepsis were included. Nineteen patients were treated with IVIg (IVIg group; 5.0 g daily for 3 days within 2 days after hospitalization), and 22 patients were not (non-IVIg group). Inflammatory and coagulation/fibrinolysis molecular markers, Japanese Association for Acute Medicine disseminated intravascular coagulation score, and the Sequential Organ Failure Assessment score were evaluated in each group. On admission, patients in the IVIg group had a significantly more severe condition. In the IVIg group, after treatment, C-reactive protein, procalcitonin, and interleukin-6 levels significantly decreased relative to values on admission. Also, compared with admission, the various coagulation/fibrinolysis molecular markers decreased after treatment. Moreover, the Japanese Association for Acute Medicine disseminated intravascular coagulation score and the Sequential Organ Failure Assessment score also significantly decreased after treat...Continue Reading

References

Jan 22, 2005·Annual Review of Medicine·Todd W Rice, Gordon R Bernard
Feb 7, 2007·Annals of Internal Medicine·Alexis F TurgeonPaul C Hébert
Jun 20, 2007·Shock·Hiroshi OguraUNKNOWN Japanese Association for Acute Medicine Disseminated Intravascular Coagulation Study Group
Dec 13, 2007·Critical Care Medicine·K Georg KreymannStefan Kluge
Dec 13, 2007·Critical Care Medicine·Karl WerdanUNKNOWN Score-Based Immunoglobulin Therapy of Sepsis (SBITS) Study Group
Oct 4, 2011·The New England Journal of Medicine·UNKNOWN INIS Collaborative GroupWilliam Tarnow-Mordi
May 30, 2014·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Kazuki MurakamiAkihito Kamizono

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Citations

Apr 20, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Asma AhmedSangita Mukhopadhyay
Jan 20, 2018·Intensive Care Medicine·Manu Shankar-HariAlexis F Turgeon
Sep 10, 2020·Biomarkers in Medicine·Gaku Takahashi, Shigehiro Shibata

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