Intravenous immunoglobulin in the therapy of adult acute fulminant myocarditis: A retrospective study

Experimental and Therapeutic Medicine
Dan-Qing YuZhi-Dan Zhu

Abstract

Acute fulminant myocarditis (AFM) is a serious heart disease with limited treatment. This observational retrospective study aimed to investigate whether intravenous immunoglobulin (IVIG) was able to improve left ventricular function and reduce the episodes of arrhythmia in adult patients with AFM. The medical records of all patients with AFM who were admitted to the Critical Care Unit of Guangdong General Hospital (Guangzhou, China) between January 2001 and December 2010 were reviewed. A cohort of 58 patients was included in the study. Of these 58, 32 patients were treated with IVIG (400 mg/kg per day) for five days, while the remaining patients did not receive IVIG therapy. The patients who received IVIG therapy had a higher left ventricular ejection fraction (LVEF) and a reduced left ventricular end-diastolic diameter (LVDD) compared with the non-IVIG therapy patients four weeks subsequent to the treatment (PLVEF=0.011 and PLVDD=0.048). The post-treatment incidence of ventricular tachycardia/ventricular fibrillation (VT/VF) and atrioventricular block (AVB) was reduced in the patients who received IVIG therapy compared with the baseline values (PVT/VF=0.025, PAVB=0.003); however, no significant differences were observed in the...Continue Reading

References

Feb 1, 1987·The Journal of Clinical Investigation·D Y LeungR S Geha
Jan 1, 1994·Circulation·N A DruckerJ W Newburger
Jun 1, 1993·Clinical Immunology and Immunopathology·F S Rosen
Dec 18, 1998·Japanese Circulation Journal·Y TakedaH Nonogi
Jan 23, 1999·The New England Journal of Medicine·Z Yu, V A Lennon
Jul 29, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G NigroS P Adler
Nov 9, 2000·The New England Journal of Medicine·A M Feldman, D McNamara
Oct 17, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Keisuke ShiojiChiharu Kishimoto
Oct 14, 2003·Clinical Pediatrics·Muhammad A KhanJayendra Sharma
Mar 12, 2004·The Pediatric Infectious Disease Journal·Chung-Yi WangLi-Min Huang
Aug 11, 2004·International Journal of Cardiology·Hae Soon KimJeong Wan Seo
Feb 1, 2005·Cardiology in the Young·Robert F EnglishSteven A Webber
Jun 4, 2005·BMC Cardiovascular Disorders·Joan L RobinsonTerry P Klassen
Feb 2, 2006·Heart·N AmabileC Ovaert
Feb 16, 2006·Circulation·Jared W Magnani, G William Dec
Feb 24, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Rie IchikawaHideo Mugishima

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Citations

Jul 18, 2014·Indian Pediatrics·Amarendra N Prasad, Sanjay Chaudhary
Sep 4, 2016·British Journal of Pharmacology·E StephensonF M Marelli-Berg
Aug 25, 2020·The Cochrane Database of Systematic Reviews·Joan RobinsonTerry P Klassen
Dec 7, 2018·Science China. Life Sciences·Daowen WangUNKNOWN Working Group of Adult Fulminant Myocarditis
Feb 13, 2019·International Heart Journal·Xin HuangXinxin Shuai
Jun 11, 2021·The Journal of Emergency Medicine·Michael GottliebBrit Long

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Methods Mentioned

BETA
AFM

Software Mentioned

Statistical Package for Social Sciences

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