Intravenous immunoglobulin (IVIg) for refractory and difficult-to-treat infections

The American Journal of Medicine
Giovanni FerraraMarkus Maeurer


Traditionally, intravenous immunoglobulin (IVIg) has been used as replacement therapy for patients with primary or secondary immunoglobulin deficiencies. Increasingly, IVIg is being used (in doses higher than for replacement therapy) in certain bacterial or viral infectious diseases. A variety of modes of action have been attributed to the beneficial effects of IVIg, including its interaction with T-cell function, antigen-presenting cell maturation/presentation, combined with a general "tune down" effect on inflammatory reactions. More often, IVIg is being evaluated in clinical trials for the treatment of refractory and difficult-to-treat chronic infections. The evidence, molecular mechanisms, and rationale for the use of adjunct IVIg therapy in infectious diseases are reviewed, and its potential use in the adjunct treatment of difficult-to-treat drug-resistant tuberculosis discussed.


Apr 1, 1993·The Journal of Experimental Medicine·F GaskinS M Fu
Sep 8, 2001·The New England Journal of Medicine·M D Kazatchkine, S V Kaveri
Jun 26, 2003·Allergy·H U Simon, P J Späth
Apr 6, 2004·Clinics in Chest Medicine·Douglas B Flieder, William D Travis
Aug 19, 2004·Respiration; International Review of Thoracic Diseases·Philippe CamusPascal Foucher
Aug 21, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Istvan PirkoMoses Rodriguez
Sep 16, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J KwekkeboomH J Metselaar
Mar 1, 2006·International Immunopharmacology·Jerry Siegel
Mar 1, 2006·International Immunopharmacology·David J Hamrock
Mar 10, 2006·Diseases of the Colon and Rectum·Stuart McPhersonSimon J Panter
Oct 25, 2006·Autoimmunity·Uriel KatzAnat Achiron
Feb 7, 2007·Annals of Internal Medicine·Alexis F TurgeonPaul C Hébert
Feb 17, 2007·Journal of Neuroscience Research·Arthur E WarringtonMoses Rodriguez
May 19, 2007·Journal of Clinical Immunology·Isabella QuintiUNKNOWN Italian Primary Immunodeficiency Network
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine A KirvanMadeleine W Cunningham
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aharon KesselElias Toubi
Mar 11, 2008·Trends in Immunology·Michal Schwartz, Yaniv Ziv
Mar 29, 2008·Annual Review of Immunology·Falk Nimmerjahn, Jeffrey V Ravetch
May 31, 2008·British Journal of Haematology·Kenichi SawadaMakoto Hirokawa
Sep 23, 2008·The Journal of Allergy and Clinical Immunology·Mark Ballow
Oct 18, 2008·Trends in Immunology·Thanyalak Tha-InJaap Kwekkeboom
Oct 23, 2008·Immunology and Allergy Clinics of North America·Maria Garcia-LloretTalal A Chatila
Dec 31, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pia RaananiOfer Shpilberg
Apr 28, 2009·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Toshiyuki KoyaFumitake Gejyo
May 26, 2009·Immunology Letters·Dominic Paquin ProulxRenée Bazin
Jul 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·M BritschgiT Wyss-Coray
Jul 17, 2009·Clinical and Experimental Immunology·F Abebe, G Bjune
Oct 1, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Samir S ShahJames E Levin
Oct 29, 2009·Bone Marrow Transplantation·D EngelhardUNKNOWN Centers for Disease Control and Prevention
Jan 8, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·J L WynnC M Cotten
Mar 20, 2010·The Cochrane Database of Systematic Reviews·Arne Ohlsson, Janet Lacy
Mar 30, 2010·European Journal of Pediatrics·Tabitha D van ImmerzeelNico G Hartwig
Apr 29, 2010·Journal of Clinical Immunology·Björn TackenbergJan D Lünemann
May 4, 2010·Journal of Clinical Immunology·Michael G Fehlings, Dung H Nguyen
Aug 3, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jordan S OrangeMahlon M Wilkes
Dec 3, 2010·Journal of Virology·Yvonne HofmeisterThomas R Kreil
Dec 17, 2010·Current HIV/AIDS Reports·Xiaoying Shen, Georgia D Tomaras

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