Intravenous immunoglobulin reduces infarct volume but not edema formation in acute stroke

Neuroimmunomodulation
Maureen WalbererTibo Gerriets

Abstract

Intravenous immunoglobulin (IVIG) is used for treatment of immunodeficiencies and autoimmune disorders. Recently, IVIG has also been shown to reduce infarct size in acute stroke. Since edema treatment can provide secondary neuroprotective effects, we conducted the present study to evaluate whether edema reduction is the underlying cause of the neuroprotective properties of IVIG in experimental stroke. Male Wistar rats received either IVIG or placebo and were subjected to temporary middle cerebral artery occlusion. 24 h after temporary middle cerebral artery occlusion, clinical evaluation and 7.0T magnetic resonance imaging were performed. Ischemic lesion volume was determined on high-resolution T(2) images. T(2) relaxation time and midline shift assessed on magnetic resonance imaging as well as brain water content detected by the wet/dry method after 24 h were measured to quantify edema formation. Pretreatment with IVIG leads to a statistically significant reduction of the ischemic lesion volume by 42% after 24 h, as compared to placebo treatment (p < 0.05). All three methods for quantifying edema formation indicated no differences between IVIG-treated and untreated animals (p > 0.05). These results suggest that the neuroprotec...Continue Reading

Citations

Jul 6, 2014·Experimental & Translational Stroke Medicine·Alexander WidiapradjaThiruma V Arumugam
Apr 18, 2015·Journal of Neuroinflammation·Ker Zhing LokThiruma V Arumugam
Jan 10, 2018·Stroke; a Journal of Cerebral Circulation·Sunghee Cho, Jiwon Yang
Apr 24, 2019·Aging and Disease·Yuanyuan MaGuo-Yuan Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.