Intravenous immunoglobulin selectively decreases circulating autoantibodies in pemphigus

Journal of the American Academy of Dermatology
Annette CzernikJ C Bystryn

Abstract

Autoantibody-mediated diseases such as pemphigus are caused by a single or very limited number of pathogenic autoantibodies. A major problem with all current therapies for these diseases is that they target all antibodies rather than selectively targeting only pathogenic antibodies. The following study was conducted to confirm observations made in a limited number of patients that suggest intravenous immunoglobulin (IVIg) may be able to selectively lower serum levels of only abnormal autoantibodies. The study was conducted in 12 patients who received IVIg for the treatment of recalcitrant pemphigus. Serum levels of antibodies to desmoglein 1 (Dsg 1) and desmoglein 3 (Dsg 3) were measured by enzyme-linked immunosorbent assay immediately before IVIg treatment and following a median of 2 cycles (range, 1-3) of treatment. As control, serum levels of several normal antibodies (against herpes simplex virus types 1 and 2, mumps, and varicella) were measured concurrently. Within a median of 2 weeks following the last cycle of IVIg serum, anti-Dsg 3 declined in all patients who tested positive at baseline and in 8 of 10 (80%) patients testing positive for anti-Dsg 1. On average, anti-Dsg 3 decreased by 45% and anti-Dsg 1 by 32%. By cont...Continue Reading

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Citations

Sep 19, 2009·Drugs & Aging·Oliver A Perez, Timothy Patton
Mar 15, 2011·Annales de dermatologie et de vénéréologie·P Joly, C Sin
Jul 1, 2011·The Journal of Investigative Dermatology·Siavash ToosiJean-Claude Bystryn
Sep 20, 2011·Autoimmunity·Annette CzernikSergei A Grando
Feb 26, 2016·Annual Review of Pathology·Christoph M Hammers, John R Stanley
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Linda K MartinDedee F Murrell
Feb 18, 2011·Experimental Dermatology·Sergei A GrandoRobert A Schwartz
Sep 22, 2018·Drugs·Kyle T AmberMichael Hertl

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