Intravenous immunoglobulin therapy in the treatment of patients with pemphigus vulgaris unresponsive to conventional immunosuppressive treatment

Journal of the American Academy of Dermatology
A Razzaque Ahmed

Abstract

Severe pemphigus vulgaris (PV) is conventionally treated with high-dose oral prednisone, usually in combination with an immunosuppressive agent (ISA). Some patients experience significant side effects, which are sometimes fatal, from prolonged immunosuppression. Intravenous immunoglobulin (IVIg) was administered to 21 patients with severe cutaneous and mucosal PV who had not responded to the prolonged use of oral prednisone and multiple ISAs. A preliminary dose-determination study tested 7 additional volunteers to ascertain the optimal IVIg dose of 2 g/kg per cycle. Parameters to assess clinical outcome were recorded before and after IVIg therapy. Variables tested were highest dose, total dose, and duration of prednisone and ISAs, their side effects, frequency of recurrence and relapse, duration of IVIg therapy, clinical response, induction and duration of remission, number of hospitalizations, total days of hospital stay, and quality of life. Use of IVIg monotherapy resulted in effective control of disease and produced a sustained remission in the 21 patients. The patients became free of lesions and remained so after finishing IVIg therapy. IVIg had a steroid-sparing effect and produced a high quality of life. Serious side eff...Continue Reading

Citations

Mar 25, 2008·Therapeutics and Clinical Risk Management·Diya F Mutasim
Feb 12, 2004·The Journal of Investigative Dermatology. Symposium Proceedings·Erwin W Gelfand
Mar 15, 2011·Annales de dermatologie et de vénéréologie·P Joly, C Sin
Aug 10, 2010·Journal of the American Academy of Dermatology·Margarita LolisJean-Claude Bystryn
Mar 19, 2009·Journal of the American Academy of Dermatology·Masayuki AmagaiUNKNOWN Pemphigus Study Group
Dec 19, 2006·Seminars in Cutaneous Medicine and Surgery·Mary Jo J KernsMichael P Heffernan
Mar 20, 2004·Veterinary Dermatology·Wayne S Rosenkrantz
Sep 27, 2003·Dermatologic Therapy·S W YehA Razzaque Ahmed
Sep 18, 2009·Annals of the New York Academy of Sciences·Enno SchmidtDetlef Zillikens
May 11, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·S BaumH Trau
Jul 22, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·D IoannidesD Rigopoulos
May 8, 2009·Pediatric Dermatology·Adam Asarch, A Razzaque Ahmed
Nov 1, 2007·Dermatologic Therapy·Anthony P Fernandez, Francisco A Kerdel
Dec 12, 2007·The British Journal of Dermatology·I ShimanovichD Zillikens
Jun 14, 2012·The Journal of Pathology·Takashi HashimotoMinao Furumura
Dec 28, 2006·Journal of the American Academy of Dermatology·David I SmithMichael P Heffernan
Oct 3, 2006·Journal of the American Academy of Dermatology·Mohsin Malik, A Razzaque Ahmed
Aug 2, 2015·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·R Eming
Jan 10, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Naveed SamiA Razzaque Ahmed
Jul 23, 2004·Expert Opinion on Investigational Drugs·A Razzaque Ahmed
Mar 1, 2006·International Immunopharmacology·A Razzaque Ahmed
Nov 30, 2005·The American Journal of Pathology·Juan ArredondoSergei A Grando
Dec 17, 2004·Annales de dermatologie et de vénéréologie·A LevyV Descamps
Jul 5, 2005·Lancet·Jean-Claude Bystryn, Jennifer L Rudolph
Jan 20, 2007·Journal of Cutaneous Medicine and Surgery·P Régine MydlarskiNeil H Shear
Jan 20, 2007·Journal of Cutaneous Medicine and Surgery·Nicole MittmannNeil Shear
Apr 19, 2007·The Annals of Pharmacotherapy·Hakan M Gürcan, A Razzaque Ahmed
Nov 6, 2003·The Journal of Biological Chemistry·Vu Thuong NguyenSergei A Grando
Sep 13, 2014·British Journal of Hospital Medicine·Martina ShephardAnne M Hegarty

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.