Abstract
In a randomized, double blind, cross-over study, human beta-endorphin or saline was infused iv over 30 min into six depressed psychiatric patients and four methadone addicts. All depressed subjects showed prompt, 2- to 4-fold increases in serum PRL levels, which lasted at least 2 h. The addicts, who were undergoing acute methadone withdrawal, showed similar PRL increases, which were dose dependent. beta-Endorphin did not increase serum levels of cortisol or GH in either group of subjects. These results suggest that iv beta-endorphin has potent but selective neuroendocrine effects in depressed patients and subjects withdrawing from methadone.
Citations
Jan 1, 1982·Cell and Tissue Research·L C SalandA T Munger
Dec 1, 1987·Journal of Neurology·C F SuM T Lin
Jan 1, 1981·Journal of Neural Transmission·L LaurianE Hoerer
Dec 21, 1981·Life Sciences·R L Reid, S S Yen
Sep 1, 1985·Metabolism: Clinical and Experimental·E C degli UbertiR Pansini
Nov 1, 1982·Regulatory Peptides·M Feldman, C H Li
May 1, 1982·Peptides·S C RischD L Murphy
Jan 1, 1985·Peptides·E C Degli UbertiR Pansini
Jan 1, 1983·Psychoneuroendocrinology·J E Morley
Jan 1, 1984·Psychoneuroendocrinology·A P ZisB J Carroll
Jan 1, 1988·Psychoneuroendocrinology·A P Zis
May 1, 1995·Experimental Gerontology·G C DesjardinsJ R Brawer
Dec 9, 1997·Fertility and Sterility·R G BrzyskiD F Archer
Mar 1, 1991·Baillière's Clinical Endocrinology and Metabolism·A P Zis, J E Garland
Feb 17, 1983·The New England Journal of Medicine·M FeldmanC H Li
Dec 29, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·J T Wahlstrom, A S Dobs
Nov 1, 1988·Medical Toxicology and Adverse Drug Experience·K Hell, H Wernze
Jan 1, 1981·Peptides·G A OlsonD H Coy
Feb 1, 1994·Journal of Pain and Symptom Management·J A PaiceW G Ryan
Nov 1, 1980·Comprehensive Psychiatry·M Fink
Jun 1, 1987·Clinical Endocrinology·S LacoumentaG M Hall
May 17, 2011·Annals of General Psychiatry·Angelo Giovanni Icro MaremmaniIcro Maremmani
Mar 1, 1989·Epilepsia·M Molaie, K Kadzielawa
Nov 1, 1986·International Journal of Peptide and Protein Research·A Jagannadha RaoC H Li
Jan 1, 1982·Annals of the New York Academy of Sciences·D H CatlinR H Gerner
Jun 1, 1985·Biological Psychiatry·R F HaskettA A Albala