PMID: 8610163Apr 2, 1996Paper

Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis

Proceedings of the National Academy of Sciences of the United States of America
R LiblauH O McDevitt

Abstract

The mechanism by which tolerance is induced via systemic administration of high doses of aqueous antigen has been analyzed by using mice transgenic for a T-cell receptor specific for the influenza virus hemagglutinin (HA) peptide comprising amino acids 126-138. After intravenous injection of 750 (but not 75) micrograms of HA peptide, a state of hyporesponsiveness was rapidly induced. In the thymus, in situ apoptosis in the cortex and at the corticomedullary junction was responsible for a synchronous and massive deletion of CD4+ CD8+ thymocytes. In secondary lymphoid organs, HA-reactive T cells were initially activated but were hyporesponsive at the single cell level. After 3 days, however, those cells were rapidly deleted, at least partially, through an apoptotic process. Therefore, both thymic and peripheral apoptosis, in addition to T-cell receptor desensitization, contribute to high-dose tolerance.

References

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C MamalakiD Kioussis
Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Jan 1, 1992·The Journal of Experimental Medicine·E E Eynon, D C Parker
Mar 8, 1991·Science·B Rocha, H von Boehmer
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M A BlackmanP Marrack
Mar 10, 1995·Science·S Nagata, P Golstein
Jun 1, 1993·Immunological Reviews·G J HämmerlingB Arnold
Jul 1, 1993·European Journal of Immunology·S A Boehme, M J Lenardo
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D SpanerR A Phillips
Feb 1, 1993·The Journal of Experimental Medicine·H J Burstein, A K Abbas
May 1, 1993·The Journal of Experimental Medicine·B RochaH Von Boehmer

❮ Previous
Next ❯

Citations

Mar 29, 2002·Diabetes/metabolism Research and Reviews·Alberto Pugliese, Donatella Miceli
May 18, 2010·Rheumatology International·Hiroto YoshidaMasahiko Mihara
Nov 12, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Joseph J SabatinoBrian D Evavold
Dec 29, 1998·Transplantation Proceedings·C BurkhartD C Wraith
Dec 5, 1997·Immunology Today·W O Weigle, C G Romball
Jan 13, 1998·Immunology Today·R LiblauH O McDevitt
Nov 24, 1999·Immunology Today·S J McSorley, P Garside
Apr 29, 1998·Immunology and Cell Biology·D O Willenborg, M A Staykova
Jul 4, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nicholette Zeliadt
Jun 13, 1998·The Journal of Experimental Medicine·W R HeathF R Carbone
Jun 13, 1998·The Journal of Experimental Medicine·S E Townsend, C C Goodnow
Dec 8, 1998·The Journal of Experimental Medicine·S R BennettW R Heath
Apr 6, 1999·The Journal of Experimental Medicine·S PingelR M Locksley
Jan 4, 2001·The Journal of Experimental Medicine·S M AndertonD C Wraith
Aug 22, 2001·The Journal of Experimental Medicine·P KrajL Ignatowicz
Oct 23, 2002·The Journal of Experimental Medicine·Kang LiuRalph M Steinman
Jul 29, 2009·The Journal of Experimental Medicine·Leona GabrysováDavid C Wraith
Jul 28, 2010·The Journal of Experimental Medicine·Rachel A GottschalkJames P Allison
Sep 16, 2000·Current Opinion in Rheumatology·R R Singh
Dec 1, 1994·Immunological Reviews·R S LiblauH O McDevitt
May 25, 2007·The Journal of Pharmacology and Experimental Therapeutics·Naoki KobayashiTeruna J Siahaan
Mar 5, 2003·Annual Review of Immunology·Ralph M SteinmanMichel C Nussenzweig
Jan 1, 2011·Clinical and Translational Allergy·Karen J MackenzieJürgen Schwarze
May 10, 2007·The Review of Diabetic Studies : RDS·Matthew A Gronski, Michael Weinem

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis