Intravenous iron attenuates postvaccination anti-HBsAg titres after quadruple hepatitis B vaccination in dialysis patients with erythropoietin therapy

International Journal of Clinical Practice
J-H LiuC-C Huang

Abstract

Anaemia in patients with end-stage renal disease (ESRD) is commonly treated with recombinant human erythropoietin (rHuEPO), often in combination with an adjuvant iron supplement. There is much evidence that rHuEPO can influence the immune response by its effect on lymphocytes. Also, iron catalyses the formation of radicals and increases the risk of major infections by negatively affecting the immune system. The relationship between antibodies to hepatitis B surface antigen (anti-HBsAg) responsiveness after hepatitis B vaccination and rHuEPO/adjuvant iron supplementation has not been reported before. To determine the effects of subcutaneous erythropoietin and intravenous (i.v.) iron therapy on the responsiveness of anti-HBsAg after quadruple hepatitis B vaccination among ESRD patients. Retrospective medical records were reviewed in a hospital with a tertiary teaching facility. Eighty-three ESRD patients, including 51 who underwent haemodialysis and 32 who underwent peritoneal dialysis therapy, received a quadruple recombinant hepatitis B vaccine. We investigated anti-HBsAg titres in those patients who either received rHuEPO alone (n = 50) or rHuEPO in combination with i.v. iron (n = 33). We found that the postvaccination anti-HB...Continue Reading

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Citations

Oct 30, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Steven FishbaneNosratola D Vaziri
Oct 3, 2012·ISRN Gastroenterology·Mohammad Hossein Somi, Babak Hajipour
Jun 12, 2013·Seminars in Dialysis·Ritu SoniMark Unruh
Jul 21, 2012·Kidney & Blood Pressure Research·Fabrizio FabriziPiergiorgio Messa
Sep 19, 2014·World Journal of Gastroenterology : WJG·Theodoros EleftheriadisIoannis Stefanidis
Apr 12, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Timna AgurBoris Zingerman
Jul 11, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Edwin Patino, Oleh Akchurin

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