Intravenous iron sucrose for children with iron deficiency anemia: a single institution study

World Journal of Pediatrics : WJP
Elpis MantadakisAthanassios Chatzimichael

Abstract

Intravenous iron sucrose is not recommended by its manufacturers for use in children despite extensive safety and efficacy data in adults. We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children ≤14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of intravenous iron sucrose. Ten patients had IDA inadequately treated or non-responsive to oral iron therapy. One patient received therapy for blood transfusion avoidance and one for presumed iron refractory iron deficiency anemia (IRIDA). Iron sucrose infusions were given on alternate days up to three times per week. The number of infusions per patient ranged from 2 to 6 (median, 3), the individual doses from 100 mg to 200 mg (median, 200 mg), and the total doses from 200 mg to 1200 mg (median, 400 mg). Iron sucrose was effective in raising the hemoglobin concentration to normal in all patients with IDA, i.e., from 7.6±2.38 g/dL to 12.4±0.64 g/dL, within 31-42 days after the first infusion. The single patient with IRIDA demonstrated a 1.8 g/dL rise. Injection site disorders in ...Continue Reading

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Citations

Jan 20, 2016·World Journal of Pediatrics : WJP·Jelena Roganovic, Elpis Mantadakis
Jul 14, 2017·Journal of Pediatric Gastroenterology and Nutrition·Ronen E SteinRobert N Baldassano
Nov 6, 2018·Pediatric Blood & Cancer·Jacquelyn M Powers, Sarah H O'Brien
Sep 17, 2015·Pediatric Blood & Cancer·Elpis Mantadakis
Feb 6, 2020·European Journal of Pediatrics·Veneranda MattielloUNKNOWN SPOG Pediatric Hematology Working Group
Apr 13, 2021·International Journal of Pharmaceutics·Riddhi Trivedi, Kalyani Barve

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