Abstract
Renal anemia is one of the commonest complications of chronic renal failure. Iron deficiency is the most common factor which affects the efficacy of recombinant human erythropoietin (EPO) therapy. Intravenous (i.v.) iron preparations are commonly used in Western countries, but iron sucrose is seldom used in Chinese patients on maintenance hemodialysis. The aim of the present study was to explore the safety and efficacy of i.v. iron sucrose in Chinese patients on maintenance hemodialysis and to explore the optimal administration frequency. One hundred and thirty-six patients on maintenance hemodialysis were involved in this randomized, controlled, parallel-group, single-center trial. Seventy patients received i.v. iron sucrose (Venofer(R), delivering 100 mg iron) twice a week for 8 weeks, then once a week for another 4 weeks. The other 66 patients received oral (p.o.) ferrous succinate 200 mg t.i.d. for 12 weeks. Levels of serum ferritin (SF), transferrin saturation (TSAT), hemoglobin (Hb) and hematocrit (Hct) were assessed at baseline and then again after 4, 8 and 12 weeks of treatment. There were no differences between i.v. and p.o. groups in terms of sex, age, duration of hemodialysis, dialysis frequency per week, EPO dosage ...Continue Reading
References
Dec 29, 2000·Seminars in Dialysis·S Fishbane, E A Kowalski
Jan 9, 2001·American Journal of Nephrology·J T McCarthyE J Bergstralh
Feb 7, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C CharytanD B Van Wyck
Apr 23, 2002·Kidney International·Beckie MichaelUNKNOWN Ferrlecit Publication Committee
Jan 14, 2004·BMC Nephrology·Harold J Manley, Darren W Grabe
Apr 22, 2004·Journal of the American Society of Nephrology : JASN·Renato M B RomanW Kline Bolton
May 6, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eberhard Ritz
Sep 16, 2004·Deutsche medizinische Wochenschrift·M K Riedel, T Morgenstern
Apr 13, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Claude JacobsAlan C Perkins
Jul 27, 2006·International Urology and Nephrology·Donald S SilverbergDoron Schwartz
Aug 9, 2006·Seminars in Dialysis·David M Spiegel
Mar 31, 2007·Kidney International·A K SinghUNKNOWN DRIVE Study Group
Citations
Aug 2, 2011·Seminars in Dialysis·Laura H Mariani, Jeffrey S Berns
Aug 21, 2013·BMJ : British Medical Journal·Edward LittonKwok M Ho
Oct 30, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Steven FishbaneNosratola D Vaziri
Dec 25, 2013·TheScientificWorldJournal·Edita ZiginskieneInga Arune Bumblyte
Jun 4, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Iain C MacdougallUNKNOWN FIND-CKD Study Investigators
Sep 5, 2014·Expert Opinion on Pharmacotherapy·Yves Beguin, Aurélie Jaspers
Aug 1, 2012·Kidney International Supplements
Jan 19, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Simona StancuGabriel Mircescu
Oct 11, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Benaya Rozen-ZviUzi Gafter
Dec 1, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nosratola D VaziriJay B Wish
Jan 13, 2015·Mayo Clinic Proceedings·Tomer AvniAnat Gafter-Gvili
May 1, 2015·PloS One·Jorge Eduardo Toblli, Federico Di Gennaro
Dec 12, 2017·Clinical Kidney Journal·Iain C Macdougall
Dec 12, 2017·Clinical Kidney Journal·Simon D Roger
Oct 5, 2016·Nephrology·Simon D RogerIain C Macdougall
Jan 20, 2012·The Cochrane Database of Systematic Reviews·Jumana AlbaramkiAngela C Webster
Feb 10, 2011·The Annals of Pharmacotherapy·Elena CoppolBrian Shepler
Aug 24, 2019·BMC Nephrology·Chieh-Li YenPao-Hsien Chu
Feb 23, 2019·The Cochrane Database of Systematic Reviews·Emma L O'LoneJonathan C Craig
Jan 18, 2017·BMC Nephrology·Iain C MacdougallUNKNOWN FIND-CKD Study investigators
Jun 23, 2020·International Journal of Nephrology·Cahyani Gita AmbarsariEka Laksmi Hidayati
Apr 17, 2020·Advances in Therapy·Iain C MacdougallIoannis E Koutroubakis
Sep 4, 2019·Advances in Chronic Kidney Disease·Pablo E PergolaTomas Ganz