Intravenous iron supplementation effect on tissue iron and hemoproteins in chronically phlebotomized lambs

The American Journal of Physiology
S F GuiangJ A Widness

Abstract

Chronic phlebotomy is an important mechanism of iron loss in premature infants. We studied inter- and intraorgan iron allocation in 10 twin lamb pairs undergoing an acute 40-50% reduction in red cell volume followed by smaller intermittent phlebotomies over an 11-day period. One twin received no supplemental iron sucrose, while the other received an average daily intravenous dose of iron sucrose of either 1 (n = 3), 2 (n = 3), 5 (n = 3), or 15 (n = 1) mg.kg-1.day-1. The total iron content of the red blood cells, liver, skeletal muscle, heart, and brain was directly related to iron dose up to 2 mg.kg-1.day-1. Tissue iron concentrations remained stable until liver iron was < 200 g/g dry wt, after which iron was preferentially directed to red blood cells over skeletal muscle, heart, and brain. Hemoprotein concentrations decreased proportionately to tissue iron, except myocardial cytochrome c, which remained preserved. Any available iron in phlebotomized, rapidly growing lambs is preferentially directed to red blood cells, and lambs require iron supplementation to maintain tissue iron and hemoprotein concentrations. A decrease in nonheme tissue iron results in the high prioritization of iron among iron-containing proteins.

References

Jan 1, 1979·Transfusion·R M KakaiyaJ W Martin
Aug 1, 1976·The Journal of Clinical Investigation·C A FinchB Mackler
Oct 1, 1975·British Journal of Haematology·P R DallmanE C Manies
Apr 1, 1992·European Journal of Biochemistry·G OrbergerR Tauber
Jul 1, 1992·The Journal of Pediatrics·C D PetryM K Georgieff
Jul 15, 1989·BMJ : British Medical Journal·I C MacdougallJ D Williams
Sep 1, 1989·The American Journal of Clinical Nutrition·M B YoudimS Yehuda
May 1, 1988·European Journal of Pediatrics·M ObladenM Stahnke
Mar 1, 1980·The American Journal of Clinical Nutrition·M A SiimesP R Dallman
May 1, 1983·Journal of Clinical Pathology·K C GatterD Y Mason
Jun 9, 1983·Biochimica Et Biophysica Acta·R H McKayE B Brown
Dec 29, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·H G KreeftenbergC H Gips
Nov 1, 1996·The Journal of Pediatrics·J A WidnessR G Strauss
Jan 1, 1996·Biology of the Neonate·C PetersJ A Widness

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