Intravenous Irons: From Basic Science to Clinical Practice

Pharmaceuticals
Sunil BhandariHal Drakesmith

Abstract

Iron is an essential trace mineral necessary for life, and iron deficiency anaemia (IDA) is one of the most common haematological problems worldwide, affecting a sixth of the global population. Principally linked to poverty, malnutrition and infection in developing countries, in Western countries the pathophysiology of IDA is primarily linked to blood loss, malabsorption and chronic disease. Oral iron replacement therapy is a simple, inexpensive treatment, but is limited by gastrointestinal side effects that are not inconsequential to some patients and are of minimal efficacy in others. Third generation intravenous (IV) iron therapies allow rapid and complete replacement dosing without the toxicity issues inherent with older iron preparations. Their characteristic, strongly-bound iron-carbohydrate complexes exist as colloidal suspensions of iron oxide nanoparticles with a polynuclear Fe(III)-oxyhydroxide/oxide core surrounded by a carbohydrate ligand. The physicochemical differences between the IV irons include mineral composition, crystalline structure, conformation, size and molecular weight, but the most important difference is the carbohydrate ligand, which influences complex stability, iron release and immunogenicity, and ...Continue Reading

References

Jun 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D B Van WyckN Levin
Feb 7, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C CharytanD B Van Wyck
Oct 31, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G ChandlerI C Macdougall
Aug 26, 2004·Kidney International·George R AronoffUNKNOWN United States Iron Sucrose (Venofer) Clinical Trials Group
Mar 11, 2005·The New England Journal of Medicine·Guenter Weiss, Lawrence T Goodnough
Apr 13, 2005·Nephron. Clinical Practice·Chaim CharytanUNKNOWN Venofer Clinical Studies Group
Sep 8, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gabriel MircescuNicolae Ursea
Sep 17, 2005·Scandinavian Journal of Gastroenterology·Kari ErichsenTrygve Hausken
Nov 16, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Glenn M ChertowJarl Ahlmén
Dec 1, 2005·Kidney International·David B Van WyckUNKNOWN United States Iron Sucrose (Venofer) Clinical Trials Group
Dec 2, 2005·Obstetrics and Gynecology·Ragip A AlAli Haberal
Sep 19, 2006·Journal of the American College of Cardiology·Aidan P BolgerCallum M Chapman
Oct 13, 2006·American Journal of Nephrology·Rajiv AgarwalAnatole Besarab
Apr 15, 2008·Nature Genetics·Karin E FinbergMark D Fleming
Jun 6, 2008·Journal of the American Society of Nephrology : JASN·Bruce S SpinowitzBrian J G Pereira
May 2, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Gabriela BencaiovaRoland Zimmermann
Nov 6, 2009·Hemodialysis International·George R BailieThomas G Valaoras
Nov 19, 2009·The New England Journal of Medicine·Stefan D AnkerUNKNOWN FAIR-HF Trial Investigators
Jan 7, 2010·Gynecologic Oncology·Penkae Dangsuwan, Tarinee Manchana
Mar 2, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Adrian Covic, Gabriel Mircescu
Apr 27, 2010·Nature Nanotechnology·Florentine M HiltyMichael B Zimmermann
Jun 1, 2010·Haematologica·Gianfranca CornaPatrizia Rovere-Querini
Jun 24, 2010·European Heart Journal·Ewa A JankowskaPiotr Ponikowski
Oct 12, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Wajeh Y QunibiSimon D Roger
Oct 20, 2010·QJM : Monthly Journal of the Association of Physicians·S SinhaP A Kalra
Mar 1, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jacques RottembourgAntoine Lafuma
Mar 29, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Markus R JahnPeter Langguth
Dec 31, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alejandro Martin-MaloPedro Aljama
Mar 16, 2012·Drug Design, Development and Therapy·Kim NordfjeldLars L Thomsen
May 23, 2012·Biochimica Et Biophysica Acta·Cole P AndersonElizabeth A Leibold
Aug 29, 2012·The Journal of Obstetrics and Gynaecology Research·Puneet Kaur KochharPranay Ghosh
Sep 11, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Katherine A BarracloughDavid W Johnson
Nov 8, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Bernd FroesslerGustaaf Dekker
Dec 12, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Chaim CharytanDavid B Bregman
Dec 19, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Stuart L GoldsteinBradley A Warady
Mar 30, 2013·American Heart Journal·Ijsbrand T KlipEwa A Jankowska

❮ Previous
Next ❯

Citations

Oct 5, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Lennart NathellStefan Wohlfeil
Feb 6, 2020·JAMA : the Journal of the American Medical Association·Myles WolfHeinz Zoller
Aug 14, 2019·PloS One·Honorata Hafke-DysAdam Biniakowski
Jun 4, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Folabomi A OladosuKevin M Hellman
Mar 27, 2019·MMW Fortschritte der Medizin·Gabriele Röhrig
Dec 11, 2019·Pharmaceuticals·Raffaella GozzelinoPaolo Arosio
Sep 10, 2019·Frontiers in Immunology·Bernardo FariaMarc A Seelen
Nov 19, 2020·Expert Opinion on Drug Safety·Xenophon KassianidesSunil Bhandari
Nov 18, 2020·Nutrients·Aditi Kumar, Matthew J Brookes
Dec 16, 2020·Expert Review of Hematology·Xenophon KassianidesSunil Bhandari
May 24, 2020·Molecular Aspects of Medicine·Benedikt SchaeferHeinz Zoller

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT02941081
NCT02642562

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.