PMID: 9660282Jul 11, 1998Paper

Intravenous ketorolac vs intravenous prochlorperazine for the treatment of migraine headaches

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
M B SeimK A Dunn

Abstract

To compare i.v. ketorolac with i.v. prochlorperazine as the initial treatment of migraine headaches in the ED. A prospective, double-blind comparison study was performed, using a convenience sample of 64 patients suffering from migraine headaches presenting to the ED at a tertiary care university teaching hospital. Patients were randomly assigned to receive either 10 mg of prochlorperazine i.v. or 30 mg of ketorolac i.v.. Patients scored the severity of their headaches using a 10-cm visual analog pain scale. An initial mark was made on the scale at the time of entry into the study and later another mark was made on a new unmarked pain scale 1 hour after medication administration. Changes in pain scores within each treatment group and between groups were analyzed using the Wilcoxon rank sum test. Prior to treatment, the patients assigned to receive prochlorperazine had a median score of 9.2 cm (mean +/- SD pain score of 8.3 cm +/- 2.1 cm), while the patients receiving ketorolac had a median score of 9.0 (mean pain score of 8.4 cm +/- 1.7 cm). There was no significant difference between the pain scores of the participants in the 2 groups prior to treatment (p = 0.80). One hour after medication administration, the patients in the ...Continue Reading

Citations

Jul 9, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Paola TorelliGian Camillo Manzoni
Mar 15, 2011·Current Pain and Headache Reports·Benjamin W Friedman, Richard B Lipton
Oct 21, 2011·Current Treatment Options in Neurology·Michael J Marmura
Feb 26, 2004·The Journal of Emergency Medicine·Christopher S WeaverWilliam H Cordell
Mar 19, 2004·The Journal of Emergency Medicine·David R Vinson
Sep 28, 1999·Annals of Emergency Medicine·D L Drotts, D R Vinson
Jun 18, 2003·The American Journal of Emergency Medicine·John T MeredithKori L Brewer
Feb 24, 2001·The Journal of Emergency Medicine·D R VinsonC P Quesenberry
Jun 17, 2003·The Neurologist·Mark W Green
Jul 1, 1999·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·G Larkin
Sep 6, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·J R MinerM H Biros
Sep 15, 2000·The Western Journal of Medicine·A M Kelly
Jul 25, 2012·CNS Drugs·Arnaldo N Da Silva, Stewart J Tepper
Jul 11, 1998·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·S Huff
Jun 17, 2010·Pharmaceuticals·Arpad Pardutz, Jean Schoenen
Aug 4, 2006·Journal of Pharmaceutical Sciences·Joshua D RabinowitzJames V Cassella
Feb 17, 2009·Emergency Medicine Clinics of North America·Benjamin Wolkin Friedman, Brian Mitchell Grosberg
May 18, 2012·The Journal of Headache and Pain·Paola SarchielliGiorgio Zanchin
Nov 17, 2007·Annals of Emergency Medicine·Benjamin W FriedmanE John Gallagher
Jan 10, 2013·Headache·Erin TaggartBrian H Rowe
Jan 19, 2010·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Benjamin W FriedmanRichard B Lipton
Apr 15, 2005·Emergency Medicine Clinics of North America·Derek R LinklaterWesley Zeger
Jul 11, 2014·Expert Opinion on Pharmacotherapy·Stephen D Silberstein, Jessica C Stirpe
Jul 15, 2016·Expert Opinion on Pharmacotherapy·Abigail L Chua, Stephen Silberstein
Aug 12, 2016·Annals of Emergency Medicine·Benjamin W Friedman
Apr 1, 2012·The Neurohospitalist·Amy A Gelfand, Peter J Goadsby
May 7, 2015·Cephalalgia : an International Journal of Headache·Faruk GungorCenker Eken
May 11, 2011·Journal of Child Neurology·Geneviève LegaultMichael I Shevell
Jun 24, 2004·Headache·Benjamin Wolkin Friedman
Apr 20, 2005·Headache·Hua C SiowStephen D Silberstein
May 5, 2001·Expert Opinion on Pharmacotherapy·D A Marcus
Dec 24, 2017·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Venkata K Yellepeddi
Mar 15, 2019·Current Pain and Headache Reports·Amir RashedAli Pourmand
Apr 18, 2019·Acta Neurologica Scandinavica·Tasha FernandoDavid A Tanen
Jan 2, 2020·Internal and Emergency Medicine·Maria Adele GiamberardinoPaolo Martelletti
Oct 2, 2020·Journal of the American College of Emergency Physicians Open·Jeffrey L JarvisRemle P Crowe
Jul 6, 2020·Emergency Medicine Journal : EMJ·Tony ZitekKhanhha Tran

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