PMID: 9536924Apr 16, 1998Paper

Intravenous lactate prevents cerebral dysfunction during hypoglycaemia in insulin-dependent diabetes mellitus

Clinical Science
P KingR B Tattersall

Abstract

1. Intravenous lactate prevents cerebral dysfunction during hypoglycaemia in healthy volunteers. This study examines whether this also occurs in insulin-dependent diabetes. Changes in four-choice reaction time, auditory brain stem response, and P300 latency were used as measures of cerebral function. 2. Ten subjects were studied twice at least 4 weeks apart. Blood glucose was maintained between 5 and 8 mmol/l for 1 h before starting a 60 m-unit min-1 m-2 stepped hyperinsulinaemic clamp, achieving blood glucose concentrations of 4.5, 3.3 and 2.5 mmol/l. At one visit, 40 mumol min-1 kg-1 sodium lactate was infused, and at the other, normal saline. Cerebral function was measured at each blood glucose concentration. 3. Blood lactate rose to 3.32 +/- 0.06 mmol/l during lactate infusion compared with 0.9 +/- 0.03 mmol/l during saline infusion. Compared with the results at 4.5 mmol/l there were no significant changes at 3.3 mmol/l in any measure of cerebral function at either visit. At 2.5 mmol/l a significant increase in reaction time and P300 latency occurred with saline [mean change 33.1 +/- 8.6 ms (P < 0.01) and 30.1 +/- 9.2 ms (P < 0.01) respectively] but not lactate [mean change -5.9 +/- 3.7 ms (P > 0.05) and -6 +/- 7.6 ms (P > ...Continue Reading

Citations

Apr 20, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·M L EvansS A Amiel
Mar 15, 2006·Biology of the Neonate·Paul J Rozance, William W Hay
Mar 30, 2010·Acta Physiologica·Gerrit van Hall
Apr 2, 2013·The Journal of Clinical Investigation·Marina LitvinSimon J Fisher
Oct 13, 2017·Physiology·Shiren SunQi Qian
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·X M Leverve
Jun 11, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Diarmuid SmithStephanie A Amiel
Feb 28, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Luc Pellerin, Pierre J Magistretti
Apr 16, 2010·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Jean-Sebastien RachoinChristopher B McFadden
Aug 13, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jean-Daniel Lalau
Mar 4, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·R McCrimmon
Apr 19, 2017·Diabetes, Obesity & Metabolism·Jean-Daniel LalauNicolas Wiernsperger
Apr 2, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gerrit van HallHenning B Nielsen
May 12, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Evita C WiegersBastiaan E de Galan
Feb 28, 2001·Diabetes, Obesity & Metabolism·J D Lalau, J M Race
Nov 17, 2011·BMC Gastroenterology·Runkuan YangJyrki Tenhunen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.