Intravenous lidocaine for effective pain relief after a laparoscopic colectomy: a prospective, randomized, double-blind, placebo-controlled study

International Surgery
EunJin AhnSeung Won Choi

Abstract

A perioperative intravenous lidocaine infusion has been reported to decrease postoperative pain. The goal of this study was to evaluate the effectiveness of intravenous lidocaine in reducing postoperative pain for laparoscopic colectomy patients. Fifty-five patients scheduled for an elective laparoscopic colectomy were randomly assigned to 2 groups. Group L received an intravenous bolus injection of lidocaine 1.5 mg/kg before intubation, followed by 2 mg/kg/h continuous infusion during the operation. Group C received the same dosage of saline at the same time. Postoperative pain was assessed at 2, 4, 8, 12, 24, and 48 hours after surgery by using the visual analog scale (VAS). Fentanyl consumption by patient-controlled plus investigator-controlled rescue administration and the total number of button pushes were measured at 2, 4, 8, 12, 24, and 48 hours after surgery. In addition, C-reactive protein (CRP) levels were checked on the operation day and postoperative days 1, 2, 3, and 5. VAS scores were significantly lower in group L than group C until 24 hours after surgery. Fentanyl consumption was lower in group L than group C until 12 hours after surgery. Moreover, additional fentanyl injections and the total number of button pu...Continue Reading

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Citations

May 20, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jibin XingZiqing Hei
Jul 6, 2017·ANZ Journal of Surgery·Wiremu S MacFaterAndrew G Hill
Jun 5, 2018·The Cochrane Database of Systematic Reviews·Stephanie WeibelPeter Kranke
Dec 18, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Cristina González-CallejasTeresa Nestares
Jan 15, 2019·Regional Anesthesia and Pain Medicine·Andres MissairOscar De Leon Casasola

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