Intravenous Lidocaine for the Prevention of Cough: Systematic Review and Meta-analysis of Randomized Controlled Trials

Anesthesia and Analgesia
Sara ClivioMartin R Tramèr

Abstract

It remains unclear to what extent intravenous lidocaine prevents cough and whether there is dose-responsiveness and risk of harm. We searched electronic databases to January 1, 2017 for randomized trials comparing intravenous lidocaine with placebo for the prevention of cough in surgical patients. Primary outcome was the incidence of cough. Data were analyzed using a random-effects model and were expressed as risk ratio (RR) and number needed to treat (NNT) with 95% confidence interval. In 20 trials in adults (n = 3062) and 5 trials in children (n = 445), intravenous lidocaine 0.5-2 mg·kg was tested for the prevention of intubation-, extubation-, or opioid-induced cough. Twenty-two trials included only American Society of Anesthesiologists I or II patients; 3 trials (n = 99) also included American Society of Anesthesiologists III patients. Lidocaine was associated with a lower incidence of cough compared to placebo in adults and children, irrespective of dosage and cough etiology. Data from adults suggested dose-responsiveness; with 0.5 mg·kg, RR was 0.66 (0.50-0.88) and NNT was 8 (5.4-14.3); with 1 mg·kg, RR was 0.58 (0.49-0.69) and NNT was 7 (4.6-8.9); with 1.5 mg·kg, RR was 0.44 (0.33-0.58) and NNT was 5 (3.3-5.2); and with ...Continue Reading

References

Jan 1, 1991·Respiratory Medicine·S YoungG J McHardy
Jul 1, 1987·The British Journal of Ophthalmology·B Drenger, J Pe'er
Dec 1, 1985·Anesthesia and Analgesia·H YukiokaM Fujimori
Jan 1, 1974·Annual Review of Medicine·D C Harrison, K A Collinsworth
Feb 17, 1972·The New England Journal of Medicine·C K FrancisB J Polansky
Apr 1, 1983·Journal of Clinical Pharmacology·H R OchsD J Greenblatt
May 1, 1994·Chest·L ReisinM Manoach
Feb 1, 1993·British Journal of Anaesthesia·J A Davidson, J A Gillespie
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Oct 30, 1998·Journal of Clinical Anesthesia·S N KhalilR Ruiz
Mar 4, 2000·European Journal of Pain : EJP·E KalsoR A Moore
May 29, 2001·Anesthesia and Analgesia·W A Tweed, D Dakin
Sep 10, 2002·BMC Musculoskeletal Disorders·J H RaphaelG D Kitas
Apr 30, 2003·Anesthesiology·Thomas MenckeThomas Fuchs-Buder
Nov 28, 1953·The Journal of Physiology·E P SHARPEY-SCHAFER
Nov 4, 1961·JAMA : the Journal of the American Medical Association·E B BENEDICT
Aug 18, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Chin-Shuang LinMartin S Mok
Jan 7, 2005·Regional Anesthesia and Pain Medicine·Per H RosenbergWilliam F Urmey
Feb 3, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Chandra Kant PandeyPrabhat Kumar Singh
Jan 20, 2006·Journal of Anesthesia·Kimiko TakekawaYasushi Kinoshita
Apr 17, 2008·Anaesthesia·J Y KimJ W Kim
Mar 2, 2010·Pulmonary Pharmacology & Therapeutics·Nausherwan K Burki, Lu-Yuan Lee
Apr 20, 2010·British Journal of Anaesthesia·J R Sneyd, E O'Sullivan
Mar 17, 2011·BMJ : British Medical Journal·Leena JalotaUNKNOWN Perioperative Clinical Research Core
Aug 21, 2013·Cough·Agreta Gecaj-GashiMusli Gashi
Oct 9, 2013·Korean journal of anesthesiology·Kyung Jee LimMae Hwa Kang

❮ Previous
Next ❯

Citations

Dec 31, 2019·Paediatric Anaesthesia·Thomas O ErbBritta S von Ungern-Sternberg
Nov 27, 2019·Paediatric Anaesthesia·Francis Veyckemans
May 13, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Andrew D P PrinceRobbi A Kupfer
Aug 18, 2020·Expert Review of Respiratory Medicine·Elzbieta M GrabczakRafal Krenke
Jul 21, 2020·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Shuai Tang, Ming Zhang Zuo
Dec 17, 2020·Frontiers in Pharmacology·Rong ChenQing-Tao Meng
Mar 31, 2021·Journal of Critical Care·M W F van den HoogenD A Hesselink
Apr 26, 2021·Brazilian Journal of Anesthesiology·Thiago Mamoru SakaeJulio Cezar Mendes Brandão
Jul 5, 2021·Respiratory Medicine·Yao-Chen WangYia-Ting Li
Jan 29, 2022·European Journal of Clinical Pharmacology·Nuanwan PhuvachoterojanaphokinSithapan Munjupong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.