Intravenous magnesium is ineffective in adult asthma, a randomized trial

European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine
R S PorterW C Dalsey

Abstract

Intravenous magnesium sulphate (MgSO4) has been tried in the emergency department treatment of asthma since the mid-1980s, but published reports vary as to its efficacy. The literature suggests that it may be effective in the more severely ill asthmatic. We evaluated i.v. MgSO4 in adult asthmatics having a moderate to severe exacerbation. The study was performed in a convenience sample of adult asthmatics between the ages of 18 and 55 presenting to the emergency department with a peak expiratory flow (PEF) of < 100 l/min or < 25% of predicted flow. Patients received either 2.0 grams of MgSO4 or placebo in a randomized, double-blind fashion. All patients received inhaled bronchodilators and i.v. steroids. Outcome variables were: improvement in PEF, subjective respiratory distress as measured by the Borg dyspnoea scale (BDS) and hospital admission. The first visits of 42 patients presenting with acute asthma exacerbations were evaluated, 18 receiving MgSO4 and 24 receiving placebo. The t = 60 peak flow in the MgSO4 group was 174 l/min versus 212 l/min in placebo, p = 0.04. Controlling for age, heart rate, initial PEF and initial BDS in ordinal logistic regression, the t = 60 Borg scale of subjective dyspnoea had an odds ratio of ...Continue Reading

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Citations

Nov 23, 2013·Current Opinion in Pulmonary Medicine·Colin V E Powell
Mar 12, 2005·BMJ : British Medical Journal·Graeme P CurrieJon G Ayres
Nov 22, 2007·Emergency Medicine Journal : EMJ·S Mohammed, S Goodacre
May 14, 2010·Trials·Kerry DwanPaula R Williamson
Feb 22, 2012·Asia Pacific Allergy·Woo-Jung Song, Yoon-Seok Chang
Aug 7, 2013·Emergency Medicine Clinics of North America·Sarah Kline-KrammesShawn Robinson
Jan 20, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Junko HirashimaHideo Yasunaga
Jul 16, 2003·Anaesthesia·Gary J Browne, Barry H Wilkins
May 18, 2016·Lung India : Official Organ of Indian Chest Society·Rahul MagazineAsha Kamath
Sep 18, 2007·Respiratory Medicine·Tracey A BradshawAndrew P Greening
Jun 1, 2006·The Annals of Pharmacotherapy·Eric J Villeneuve, Peter J Zed
Aug 8, 2018·American Journal of Veterinary Research·Ludovic TanquerelMathilde Leclere
Jan 3, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Kohei HasegawaCarlos A Camargo

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