Intravenous methyl prednisolone in patients with solitary cysticercus granuloma: a random evaluation

Seizure : the Journal of the British Epilepsy Association
S PrakashManeesh Kumar Singh

Abstract

To evaluate the role of intravenous methyl prednisolone in patients with solitary cysticercus granuloma with new-onset seizures. In this open-label, randomized, prospective, follow-up study, 52 patients with new-onset seizures and a single enhancing CT lesion of cysticercus were randomly divided in two groups to receive either intravenous methyl prednisolone for 5 days along with antiepileptic drug (n=25) or antiepileptic drug monotherapy (n=27) alone. The patients were followed up for at least for 9 months. Repeat CT scans were performed after 2 months. After 2 months, lesion disappeared in 60% patients of intravenous methyl prednisolone group and 18.5% patients receiving only antiepileptic drug (p=0.001). As far as seizure recurrence was concerned, a lower number (16% versus 33%) of intravenous methyl prednisolone treated patient had recurrence, the difference was insignificant. Intravenous methyl prednisolone therapy helps in early resolution of solitary cysticercus granuloma.

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Citations

Jun 19, 2012·Expert Review of Anti-infective Therapy·Ravindra Kumar Garg, Hardeep Singh Malhotra
Jul 30, 2011·Expert Review of Neurotherapeutics·Theodore E NashUNKNOWN Cysticercosis Group in Peru
Apr 7, 2009·Headache·Sanjay PrakashNidhhi Tandon
Apr 30, 2013·Epilepsia·Gagandeep SinghJosemir W Sander
Aug 6, 2014·Epilepsia·Hector H GarciaUNKNOWN Cysticercosis Working Group in Peru
Jan 24, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Carlos A Cuello-GarcíaJorge Villarreal-Careaga
Feb 6, 2016·PLoS Neglected Tropical Diseases·Bing-Cheng ZhaoKe-Bing Chen
Jun 19, 2015·The Cochrane Database of Systematic Reviews·Vishal MehtaGayatri Vadlamani
Jun 20, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Javier A BustosUNKNOWN Cysticercosis Working Group in Peru

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