Abstract
To evaluate the role of intravenous methyl prednisolone in patients with solitary cysticercus granuloma with new-onset seizures. In this open-label, randomized, prospective, follow-up study, 52 patients with new-onset seizures and a single enhancing CT lesion of cysticercus were randomly divided in two groups to receive either intravenous methyl prednisolone for 5 days along with antiepileptic drug (n=25) or antiepileptic drug monotherapy (n=27) alone. The patients were followed up for at least for 9 months. Repeat CT scans were performed after 2 months. After 2 months, lesion disappeared in 60% patients of intravenous methyl prednisolone group and 18.5% patients receiving only antiepileptic drug (p=0.001). As far as seizure recurrence was concerned, a lower number (16% versus 33%) of intravenous methyl prednisolone treated patient had recurrence, the difference was insignificant. Intravenous methyl prednisolone therapy helps in early resolution of solitary cysticercus granuloma.
References
Dec 1, 1991·Acta Neurologica Scandinavica·V Rajshekhar
Jun 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·V RajshekharP M Schantz
Jun 1, 1990·Journal of Tropical Pediatrics·R KumarB Sharma
Jul 1, 1994·Neurology·M V PadmaG K Ahuja
Sep 3, 1998·The Pediatric Infectious Disease Journal·A K BaranwalS C Singhi
Sep 19, 1998·Journal of the Neurological Sciences·J M Murthy, Y V Subba Reddy
Jun 13, 2001·Infection and Immunity·B I RestrepoJ M Teale
Jan 5, 2002·Neurology·V Rajshekhar
Jan 17, 2002·Seizure : the Journal of the British Epilepsy Association·M K SinghS Misra
Jun 5, 2002·Journal of Neuroimmunology·J I AlvarezB I Restrepo
Dec 11, 2002·Neurology·Arturo Carpio, W Allen Hauser
Aug 14, 2003·The Journal of Pediatrics·Veena KalraVirender Kumar
Nov 26, 2003·Epilepsia·Ravi Kant MallRakesh Shukla
Jan 16, 2004·The New England Journal of Medicine·Héctor H GarciaUNKNOWN Cysticercosis Working Group in Peru
Jul 1, 2004·Journal of Child Neurology·Pratibha SinghiNarendra Khandelwal
Citations
Jun 19, 2012·Expert Review of Anti-infective Therapy·Ravindra Kumar Garg, Hardeep Singh Malhotra
Jul 30, 2011·Expert Review of Neurotherapeutics·Theodore E NashUNKNOWN Cysticercosis Group in Peru
Oct 31, 2009·Journal of the Neurological Sciences·A de SouzaK Thennarasu
Oct 15, 2008·Journal of the Neurological Sciences·Aaron de SouzaA Nalini
Apr 7, 2009·Headache·Sanjay PrakashNidhhi Tandon
Sep 9, 2008·Epilepsia·Gagandeep Singh, Sudesh Prabhakar
Jul 23, 2011·Epilepsia·Monika SinglaVivek Lal
Apr 30, 2013·Epilepsia·Gagandeep SinghJosemir W Sander
Aug 6, 2014·Epilepsia·Hector H GarciaUNKNOWN Cysticercosis Working Group in Peru
Jan 24, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Carlos A Cuello-GarcíaJorge Villarreal-Careaga
Feb 6, 2016·PLoS Neglected Tropical Diseases·Bing-Cheng ZhaoKe-Bing Chen
Jun 19, 2015·The Cochrane Database of Systematic Reviews·Vishal MehtaGayatri Vadlamani
Jun 20, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Javier A BustosUNKNOWN Cysticercosis Working Group in Peru
Apr 1, 2021·PLoS Neglected Tropical Diseases·Annette AbrahamAndrea S Winkler