Intravenous morphine administration and reperfusion success in ST-elevation myocardial infarction: insights from cardiac magnetic resonance imaging

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Suzanne de WahaHolger Thiele

Abstract

Intravenous (IV) morphine has been shown to be independently associated with adverse clinical outcome in patients with non-STEMI. Currently, there are no data on the association of IV morphine and reperfusion success in STEMI. Thus, we thought to analyse the impact of IV morphine on ischemic injury and salvaged myocardium assessed by cardiac magnetic resonance imaging (CMR) in patients with STEMI reperfused by primary coronary intervention (PCI). STEMI patients reperfused by primary PCI (n = 276) within 12 h after symptom onset underwent CMR 3 days after the index event [interquartile range (IQR) 2-4]. IV morphine administration was recorded in all patients. IV morphine was administered in 44.7% (n = 123) of all patients. Patients in the IV morphine group displayed larger infarct size, higher extent of MO and lower myocardial salvage index (MSI) in comparison to the non-IV morphine group (all p < 0.05). In multivariable logistic regression analysis adjusted for TIMI-flow pre-PCI, time from symptom onset to PCI, Killip class and left ventricular ejection fraction, IV morphine was identified as an independent predictor for MSI <median (odds ratio 1.71, 95% CI 1.02-2.87, p = 0.04). In patients with STEMI, IV morphine administratio...Continue Reading

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Citations

Feb 15, 2016·The Canadian Journal of Cardiology·Pishoy GoudaRobert Welsh
Oct 10, 2015·European Journal of Clinical Investigation·Eva-Luise HoblBernd Jilma
Oct 24, 2015·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Eva-Luise HoblBernd Jilma
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Apr 30, 2016·International Journal of Cardiology·Jacek KubicaPaul Alfred Gurbel
Dec 10, 2017·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Stephane FournierUNKNOWN on behalf on the AMIS Plus Investigators
Nov 23, 2017·Journal of Interventional Cardiology·Cian P McCarthyJason H Wasfy
Feb 15, 2018·Journal of the American Heart Association·Mickael BoninUNKNOWN CIRCUS Study Investigators
Sep 3, 2016·Circulation. Cardiovascular Interventions·Georgios GiannopoulosDimitrios Alexopoulos
Oct 26, 2018·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Frédéric LapostolleUNKNOWN ATLANTIC Investigators
Mar 16, 2018·The Journal of Pharmacology and Experimental Therapeutics·Johann BartkoEva-Luise Hobl
Oct 28, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Riley BatchelorWilliam Chan
Jul 29, 2020·Open Heart·Himawan FernandoUNKNOWN AVOID investigators
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Jan 15, 2019·Journal of the American Heart Association·Manne HolmJan van der Linden
Mar 23, 2017·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Alexander SchuhMichael Becker
Jan 17, 2021·Current Problems in Cardiology·Catherine H MooreRami N Khouzam
Aug 21, 2020·Biochemical and Biophysical Research Communications·Gabriel GawedaLisandra E de Castro Brás
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Aug 24, 2021·European Heart Journal·Himawan FernandoDion Stub
Oct 31, 2020·European Journal of Pharmacology·Li-Ning WuJun-Ma Yu

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