Intravenous morphine reduces plasma endothelin 1 concentration through activation of neutral endopeptidase 24.11 in patients with myocardial infarction

Annals of Emergency Medicine
T L Wang, H Chang

Abstract

Morphine has multiple cardiovascular effects, but its action on hydrolysis of endothelin 1 (ET-1) has not been investigated. We measured plasma levels of ET-1, C-terminal degradation products of ET-1, and neutral endopeptidase 24.11 (NEP) in 68 patients with acute Q-wave myocardial infarction and 29 control subjects. All the patients underwent blood sampling at initial presentation and 10 minutes later. Thirty-six of those with Q-wave myocardial infarction intravenously received 3 mg of morphine immediately after the first sampling (group 1), and the other 32 received the same after the second sampling (group 2). Twenty-four of the control subjects (group 3) were randomized to the protocol of group 1, and the remaining 5 subjects (group 4) were randomized to the protocol of group 2. The plasma ET-1 levels were significantly higher in groups 1 and 2 than in groups 3 and 4 (control groups). In group 1, the ET-1 level decreased significantly at second blood samplings (2.5+/-0.4 pmol/L versus 1.7+/-0.6 pmol/L, P <.001), whereas there were no definite changes of ET-1 levels in group 2 (2.5+/-0.5 pmol/L versus 2.6+/-0.6 pmol/L, P =not significant). However, the C-terminal degradation products increased significantly at second blood s...Continue Reading

References

Sep 28, 1990·Biochemical and Biophysical Research Communications·R GalronM Sokolovsky
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G B StefanoB Scharrer
Mar 31, 1993·Biochemical and Biophysical Research Communications·J A WinklesP Libby

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Citations

May 27, 2004·Expert Opinion on Therapeutic Targets·Sheila A Doggrell
Aug 16, 2005·Scandinavian Cardiovascular Journal : SCJ·Arnfinn IlebekkTorstein Lyberg
Jul 4, 2003·Canadian Journal of Physiology and Pharmacology·P D'Orléans-JusteJ Labonté
Jan 27, 2005·Neurochemistry International·G LarrinagaJ Irazusta

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