Intravenous nitroglycerin in experimental cerebral vasospasm. A preliminary report

Stroke; a Journal of Cerebral Circulation
J P KistlerR G Ojemann


Cerebral arteriospasm is a common complication of subarachnoid hemorrhage and is responsible for much of the brain damage which accompanies it. No pharmacologic agent has been found which regularly alleviates arteriospasm. We have evaluated the effect of continuous intravenous nitroglycerin infusion on the diameter of the basilar artery in dogs with cerebral vasospasm experimentally induced by subarachnoid blood injection. In 6 consecutive dogs, 10 minutes after beginning intravenous nitroglycerin at 100 microgram/min and at other times during 120 minutes of infusion, the diameter of the basilar artery had increased from 75 +/- 2% of control value to 114 +/- 2% of control value (p less than 0.001). In all 6 dogs, the basilar artery diameter during infusion was greater than the control value prior to creating subarachnoid hemorrhage. Intravenous nitroglycerin caused only a moderate (8%) decrease in blood pressure. Further investigation of the effects of nitroglycerin on cerebral vasospasm is warranted.


Dec 1, 1973·The American Journal of Physiology·R F Lowe, D D Gilboe
Apr 1, 1970·Journal of Neurosurgery·J KappG L Odom
Sep 1, 1970·Stroke; a Journal of Cerebral Circulation·M S Mahaley, J Kapp
Aug 1, 1968·Journal of Neurosurgery·R H WilkinsG L Odom
Dec 1, 1964·Archives of Neurology·S A SCHNECK, I I KRICHEFF
Jan 1, 1965·Journal of Neurosurgery·J M ALLCOCK, C G DRAKE


May 18, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Meng QiJixin Shi
Jan 5, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·M Kamran Athar, Joshua M Levine
May 1, 1995·Pharmacology & Therapeutics·D A Cook
Jul 23, 2003·European Journal of Pharmacology·Sheng-Xing MaGoodluck Ojije
Nov 20, 1998·Journal of Cardiovascular Pharmacology·M KimuraJ T Robertson
Jan 1, 1992·Acta Anaesthesiologica Scandinavica. Supplementum·M Lagerkranser
Oct 24, 1992·BMJ : British Medical Journal·M Boggild
Dec 1, 1980·Journal of Neurosurgery·E J DolanK F Hughes
Dec 24, 2005·Expert Opinion on Drug Safety·Mehmet Akif Topcuoglu, Aneesh B Singhal
Nov 22, 2011·World Neurosurgery·Robert G WhitmoreSherman C Stein
Jun 16, 2007·Journal of the Neurological Sciences·Ricardo J KomotarE Sander Connolly
May 9, 2006·Critical Care Clinics·Denise H Rhoney, Xi Liu-DeRyke
Aug 1, 1985·Surgical Neurology·S HaciyakupoğluA Yücesoy
Dec 1, 1983·Annals of Neurology·R C HerosV Varsos
Jun 17, 2004·Neurological Research·Michael ReinertRolf Seiler
Oct 28, 2008·Neurological Research·Marc L OttenRobert A Solomon
Apr 1, 2008·Journal of Cardiovascular Pharmacology and Therapeutics·Diane L Guettler, Sheng-Xing Ma
Oct 24, 1992·BMJ : British Medical Journal·J R HughesA W du Vivier
Oct 24, 1992·BMJ : British Medical Journal·V M Oh

Related Concepts

Structure of Basilar Artery
Diastolic Blood Pressure
Crescendo Transient Ischemic Attacks
Cerebrovascular Circulation
Canis familiaris
Parenteral Infusion
Subarachnoid Hemorrhage, Spontaneous
Pulmonary Vascular Resistance

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