Intravenous omeprazole: effect of a loading dose on 24-h intragastric pH

Alimentary Pharmacology & Therapeutics
J AndersenA Walan

Abstract

To determine the effect of three times daily dosing with intravenous omeprazole on intragastric acidity, 24 h intragastric pH was measured continuously with a monocrystalline antimony electrode system in II patients with inactive duodenal ulceration during fasting conditions. After a baseline investigation, two different dosage regimens of intravenous omeprazole were compared in a double-blind crossover study, with regard to their ability to keep the pH greater than or equal to 4 for as long as possible. Success in the individual patient was defined as pH greater than or equal to 4 for at least 90% over the 24-h period. Two doses of omeprazole [40 mg t.d.s. (120 mg) and 80 mg + 40 mg + 40 mg (160 mg)] were compared. Omeprazole (120 mg) increased the median of individual median intragastric 24-h pH from 1.49 to 6.67. The pH was greater than or equal to 4 for greater than or equal to 90% of the 24 h in three of the 11 patients. With omeprazole, 160 mg (a loading dose of 80 mg), the median of individual median intragastric 24-h pH increased to 7.33. The pH was greater than or equal to 4 for greater than or equal to 90% of the 24 h in seven of the 11 patients. Median time to reach pH 4 was 39 min after 40 mg and 20 min after 80 mg ...Continue Reading

Citations

Sep 25, 2001·Journal of Pediatric Gastroenterology and Nutrition·C FaureE Jacqz-Aigrain
Jul 29, 2016·Alimentary Pharmacology & Therapeutics·T KagawaT Inaba
Apr 2, 2011·World Journal of Gastrointestinal Endoscopy·Hsiu-Chi Cheng, Bor-Shyang Sheu
Dec 14, 1999·Alimentary Pharmacology & Therapeutics·A N BarkunR N Fedorak
Jan 16, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Li YangShiming Yang
May 1, 2021·The American Journal of Gastroenterology·Loren LaineGrigorios I Leontiadis
Jun 28, 2006·Medicina clínica·Javier P Gisbert

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