Intravenous or oral administration of vinorelbine in adjuvant chemotherapy with cisplatin and vinorelbine for resected NSCLC

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Steffen Filskov SorensenPeter Meldgaard

Abstract

Cisplatin and vinorelbine given intravenously is a well-established adjuvant chemotherapy regimen after surgery for early-stage NSCLC. Vinorelbine can also be administered orally. However, the efficacy of orally administrated vinorelbine in adjuvant treatment of NSCLC is unknown. We assessed the overall survival (OS) and disease-free survival (DFS) of patients treated with adjuvant i.v. vinorelbine or p.o. vinorelbine, in combination with i.v. cisplatin. We reviewed two time-separated cohorts of patients referred to the Department of Oncology at Aarhus University Hospital (Denmark) from 2005 to 2012 for adjuvant chemotherapy after surgery for NSCLC. Of the 265 patients included in this study, 126 patients received i.v. and 139 received p.o. vinorelbine/cisplatin. The two groups were comparable with respect to important baseline characteristics. Median OS for all patients was 78.7 months and the median DFS was 35.7 months. No statistically significant difference in OS or DFS for patients treated with i.v. or oral vinorelbine was detected. The DFS rates of the two groups were comparable across all variables in subgroup analysis. In conclusion we observed that intravenous or oral administration of vinorelbine in combination with c...Continue Reading

References

Aug 1, 1995·The Annals of Thoracic Surgery·J C NesbittC F Mountain
Nov 14, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·M J Moreno de VegaA Garcia-Diez
Oct 29, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J JassemF Lefresne
Jan 23, 2004·The New England Journal of Medicine·Rodrigo ArriagadaUNKNOWN International Adjuvant Lung Cancer Trial Collaborative Group
May 21, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M E R O'BrienF Lefresne
Mar 22, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M De LenaJ Gasmi
Jun 24, 2005·The New England Journal of Medicine·Timothy WintonUNKNOWN National Cancer Institute of the United States Intergroup JBR.10 Trial Investigators
Jan 9, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yuh-Min ChenPan-Chyr Yang
Mar 29, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Lars Henrik JensenCarsten Rytter
May 29, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Pierre PignonUNKNOWN LACE Collaborative Group
Mar 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tristan D YanBrian C McCaughan
Jul 1, 2008·The Patient·Candida M MastroianniUNKNOWN Gruppo Oncologico Calabrese Multidisciplinare (GOCaM)
Aug 21, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Christopher CaoJianxing He
Aug 28, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Glenwood D GossFrances A Shepherd
Dec 3, 2013·Patient Preference and Adherence·Makoto IshitobiHideo Inaji

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