Intravenous palonosetron increases the incidence of QTc prolongation during sevoflurane general anesthesia for laparotomy

Korean journal of anesthesiology
Jeong Jin MinJung-Man Lee

Abstract

Palonosetron is a recently introduced 5-hydroxytryptamine-3 (5-HT3) receptor antagonist useful for postoperative nausea and vomiting prophylaxis. However, 5-HT3 receptor antagonists increase the corrected QT (QTc) interval in patients who undergo general anesthesia. This retrospective study was performed to evaluate whether palonosetron would induce a QTc prolongation in patients undergoing general anesthesia with sevoflurane. We reviewed a database of 81 patients who underwent general anesthesia with sevoflurane. We divided the records into palonosetron (n = 41) and control (n = 40) groups according to the use of intraoperative palonosetron, and analyzed the electrocardiographic data before anesthesia and 30, 60, 90, and 120 min after skin incision. Changes in the QTc interval from baseline, mean blood pressure, heart rate, body temperature, and sevoflurane concentrations at each time point were compared between the two groups. The QTc intervals at skin incision, and 30, 60, 90, and 120 min after the skin incision during general anesthesia were significantly longer than those at baseline in the two groups (P < 0.001). The changes in the QTc intervals were not different between the two groups (P = 0.41). However, six patients i...Continue Reading

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Citations

Sep 10, 2014·Expert Opinion on Drug Safety·Louise BryggerUNKNOWN Academy of Geriatric Cancer Research (AgeCare)
Apr 23, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Carolyn Dicus BrookesJay A Anderson
May 23, 2014·Korean journal of anesthesiology·Jeounghyuk Lee, Junyong In

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