Intravenous pamidronate in patients with tumor-induced osteolysis: a biochemical dose-response study

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
J J BodyJ Ford

Abstract

Bisphosphonates are used increasingly in normocalcemic patients for treating tumor-induced osteolysis (TIO) but little is known about the metabolic effects and the most appropriate therapeutic regimen. In 21 patients with breast cancer and TIO, we determined the biochemical effects of a single infusion of pamidronate given at 30 mg (n = 5), 60 mg (n = 5), 90 mg (n = 5), or 120 mg (n = 6). Patients received no other systemic antineoplastic therapy during the trial. We selected patients with baseline fasting urinary Ca/Creat (creatinine) > 0.105 mg/mg (median value of our normal range) and they were followed weekly for up to 14 weeks. The biochemical effects were maximal at day 7. For the whole group, mean (+/- SEM) Ca/Creat levels fell from 0.208 +/- 0.018 to 0.048 +/- 0.008 mg/mg on day 7 and remained significantly ( p < 0.01) lower than baseline up to day 56. Hydroxyproline excretion fell to a lesser degree, from 7.0 +/- 1.2 to 4.0 +/- 0.6 mg x 100/mg of Creat. The falls in Ca/Creat and hydroxyproline excretion were dose-related (ANCOVA, p < 0.05). Changes in serum parameters of calcium metabolism were, however, not significantly dose-related. Serum Ca levels fell from 9.3 +/- 0.1 to 8.7 +/- 0.1 mg/dl on day 7, but not patient...Continue Reading

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Citations

Jul 1, 1996·Cancer Treatment Reviews·J J BodyM Piccart
Feb 2, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jean-Jacques Body
Nov 6, 2003·Clinical Orthopaedics and Related Research·John H HealeyGene R DiResta

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