Intravenous Paracetamol Decreases Requirements of Morphine in Very Preterm Infants

The Journal of Pediatrics
Antti HärmäTimo Saarela

Abstract

To determine whether intravenous paracetamol therapy is effective in pain therapy in premature infants. From June 2009 to December 2011, 108 infants born very low gestational age (<32 weeks) (VLGA) were given intravenous paracetamol before the age of 72 hours. The loading dose was 20 mg/kg followed by 7.5 mg/kg every 6 hours. One hundred ten VLGA infants admitted from October 2007 to May 2009 formed the comparison group who received no paracetamol. Intravenous morphine was exclusively used as the opiate. Morphine dosage was calculated as the cumulative dose administered during the neonatal intensive care unit period. Pain symptoms were screened using pain scale scoring Neonatal Infant Acute Pain Assessment Scale. The number of apneas during the neonatal intensive care unit stay, and ventilation days per patient, were calculated. The mean (SD) total number of paracetamol doses per patient was 16.9 (11.7), and the postnatal age for the first dose was 13.3 (13.8) hours. Infants in the paracetamol group needed significantly fewer morphine doses per patient than the comparisons, 1.78 (4.56) doses vs 4.35 (11.53), P = .044. The exposed had lower cumulative morphine dosage 0.17 (0.45) mg/kg vs 0.37 (0.96) mg/kg, P = .047. There were n...Continue Reading

References

May 1, 1991·Pediatric Research·G M AdamsonA W Harman
Jun 23, 2001·Archives of Disease in Childhood. Fetal and Neonatal Edition·G K IsbisterI M Whyte
Jan 9, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·K AllegaertH Devlieger
Apr 9, 2004·European Journal of Clinical Pharmacology·Karel AllegaertDick Tibboel
Dec 3, 2005·Pediatrics·Richard A EhrenkranzUNKNOWN National Institutes of Child Health and Human Development Neonatal Research Network
Jan 31, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·L WallsS Sarkar
Dec 20, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·G MenonK J S Anand
Apr 4, 2008·Paediatric Anaesthesia·Karel AllegaertGunnar Naulaers
Jul 3, 2008·JAMA : the Journal of the American Medical Association·Ricardo CarbajalGérard Bréart
Sep 25, 2008·Paediatric Anaesthesia·Brian J Anderson
Apr 2, 2009·Paediatric Anaesthesia·Brian J Anderson, Karel Allegaert
Sep 30, 2009·Pain·C V BellieniG Buonocore
Jan 19, 2010·Paediatric Anaesthesia·Daniel G Nevin, Jacinta Shung
Apr 28, 2010·Pediatrics·Shannon E G Hamrick, Georg Hansmann
Feb 15, 2011·Archives of Disease in Childhood·Karel AllegaertBrian J Anderson
Jan 10, 2012·European Journal of Clinical Pharmacology·Roser PortaMarta Martínez
Apr 3, 2013·Neuropharmacology·Linda Engström RuudAnders Blomqvist
Apr 27, 2013·Paediatric Anaesthesia·Karel AllegaertJohn van den Anker
Aug 27, 2013·Clinics in Perinatology·Lynne G MaxwellMaria V Fraga
Oct 12, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Outi AikioMikko Hallman
Dec 18, 2013·Paediatric Anaesthesia·Suellen M Walker
May 13, 2014·International Journal of Nursing Studies·Tarja PölkkiHelena Laukkala
Dec 3, 2014·Clinics in Perinatology·Richard W Hall, Kanwaljeet J S Anand

❮ Previous
Next ❯

Citations

Oct 23, 2015·The Journal of Pediatrics·John N van den Anker, Karel Allegaert
Jul 2, 2016·The Journal of Pharmacy and Pharmacology·Anne SmitsKarel Allegaert
Jul 28, 2016·The Journal of Pediatrics·John N van den Anker, Karel Allegaert
Dec 16, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·K L ChenJ L Oei
Nov 2, 2016·The Cochrane Database of Systematic Reviews·Arne Ohlsson, Prakeshkumar S Shah
Jan 28, 2020·The Cochrane Database of Systematic Reviews·Arne Ohlsson, Prakeshkumar S Shah
Aug 9, 2020·Pediatric Quality & Safety·Raymond C StetsonJane E Brumbaugh
Dec 5, 2020·Paediatric Anaesthesia·Navil F SethnaDavid Zurakowski
Oct 28, 2019·Clinics in Perinatology·Jamesia DonatoTamorah Lewis
Dec 17, 2020·BMJ Paediatrics Open·Samira Samiee-ZafarghandyJohn Van Den Anker
Sep 19, 2020·Archives of Disease in Childhood. Fetal and Neonatal Edition·Sanna JuujärviOuti Aikio
Feb 23, 2021·The Journal of Pediatrics·Clyde J Wright
Mar 4, 2021·Acta Paediatrica·Mikko HallmanJean-Christophe Rozé
Apr 11, 2019·Seminars in Fetal & Neonatal Medicine·Manon Tauzin, Xavier Durrmeyer
Aug 23, 2019·Clinical Therapeutics·Anthony SquillaroLorraine I Kelley-Quon
Jul 3, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Angelica KresnamurtiIwan Sahrial Hamid
Jul 28, 2021·Clinical Pharmacology and Therapeutics·Naïm BouazzaMikko Hallman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Outi AikioMikko Hallman
© 2021 Meta ULC. All rights reserved